Increased Ammonium Toxicity in Response to Exogenous Glutamine in Metastatic Breast Cancer Cells.

ammonium toxicity breast cancer glutamine metabolism metabolic reprogramming metastasis

Journal

Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790

Informations de publication

Date de publication:
23 May 2022
Historique:
received: 17 12 2021
revised: 20 05 2022
accepted: 20 05 2022
entrez: 28 5 2022
pubmed: 29 5 2022
medline: 29 5 2022
Statut: epublish

Résumé

Several cancers, including breast cancers, show dependence on glutamine metabolism. The purpose of the present study was to determine the mechanistic basis and impact of differential glutamine metabolism in nonmetastatic and metastatic murine mammary cancer cells. Universally labeled

Identifiants

pubmed: 35629973
pii: metabo12050469
doi: 10.3390/metabo12050469
pmc: PMC9145280
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NCI NIH HHS
ID : R01 CA232589
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197627
Pays : United States
Organisme : NIH HHS
ID : R01CA232589, R35CA197627, R01CA207751, R21AA026675
Pays : United States

Références

Biomark Insights. 2018 Feb 06;13:1177271918755391
pubmed: 29449774
Nat Rev Cancer. 2012 Nov;12(11):741-52
pubmed: 23018234
Cancer Discov. 2020 Dec;10(12):1797-1807
pubmed: 33139243
Cell Metab. 2016 Mar 8;23(3):517-28
pubmed: 26853747
Front Oncol. 2020 Oct 26;10:589508
pubmed: 33194749
Oncotarget. 2015 Dec 1;6(38):40655-66
pubmed: 26528759
Cytotechnology. 1996 Jan;22(1-3):251-4
pubmed: 22358935
Dev Cell. 2016 Mar 7;36(5):540-9
pubmed: 26954548
Cancer Prev Res (Phila). 2012 Jul;5(7):930-42
pubmed: 22588949
J Clin Invest. 2015 Feb;125(2):551-62
pubmed: 25562323
J Clin Invest. 2015 Feb;125(2):687-98
pubmed: 25607840
Free Radic Biol Med. 2012 Jan 1;52(1):1-6
pubmed: 22027063
Nat Protoc. 2019 Oct;14(10):2856-2877
pubmed: 31471597
Oncogene. 2010 Jan 21;29(3):313-24
pubmed: 19881548
Trends Cell Biol. 2020 May;30(5):408-424
pubmed: 32302552
Trends Cancer. 2017 Mar;3(3):169-180
pubmed: 28393116
Cancer Lett. 2017 Dec 28;411:171-181
pubmed: 29024812
Science. 2012 May 25;336(6084):1040-4
pubmed: 22628656
Cell Rep. 2016 Oct 11;17(3):837-848
pubmed: 27732858
Br J Cancer. 2017 May 23;116(11):1375-1381
pubmed: 28441384
Kidney Int. 1999 Mar;55(3):778-92
pubmed: 10027916
Annu Rev Biomed Eng. 2017 Jun 21;19:163-194
pubmed: 28301735
Methods Enzymol. 2014;542:369-89
pubmed: 24862276
Biotechnol Bioeng. 1994 Mar 15;43(6):505-14
pubmed: 18615748
Biomark Med. 2010 Apr;4(2):241-63
pubmed: 20406068
Cancer Res. 2015 Feb 1;75(3):554-65
pubmed: 25511375
Nat Commun. 2019 Jan 14;10(1):201
pubmed: 30643150
Cell. 2017 Mar 9;168(6):960-976
pubmed: 28283069
Cell Signal. 2014 Nov;26(11):2397-405
pubmed: 25041845
Nat Commun. 2016 Jun 20;7:11971
pubmed: 27321283
Biotechnol Bioeng. 1995 Jul 5;47(1):96-105
pubmed: 18623371
Cell. 2015 Jan 29;160(3):393-406
pubmed: 25601461
Cell. 2014 Dec 18;159(7):1603-14
pubmed: 25525878
Cell. 2009 Feb 6;136(3):521-34
pubmed: 19203585
Free Radic Res. 2010 May;44(5):479-96
pubmed: 20370557
Cell Metab. 2015 Dec 1;22(6):1068-77
pubmed: 26603296
J Biotechnol. 1996 May 15;46(3):161-85
pubmed: 8672289
Sci Rep. 2017 Nov 23;7(1):16159
pubmed: 29170516
Science. 2017 Nov 17;358(6365):941-946
pubmed: 29025995
J Cell Physiol. 1998 Jul;176(1):166-78
pubmed: 9618156
Biochim Biophys Acta. 2001 Oct 1;1514(2):291-302
pubmed: 11557028
Nature. 2013 Apr 4;496(7443):101-5
pubmed: 23535601
NPJ Breast Cancer. 2017 Jul 17;3:26
pubmed: 28748213
Cell Metab. 2015 Oct 6;22(4):577-89
pubmed: 26365179
Exp Mol Med. 2020 Sep;52(9):1496-1516
pubmed: 32943735
Nature. 2009 Apr 9;458(7239):762-5
pubmed: 19219026

Auteurs

Violet A Kiesel (VA)

Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.

Madeline P Sheeley (MP)

Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.

Shawn S Donkin (SS)

Department of Animal Science, Purdue University, West Lafayette, IN 47907, USA.

Michael K Wendt (MK)

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
The Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.

Stephen D Hursting (SD)

Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA.

Dorothy Teegarden (D)

Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.
The Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.

Classifications MeSH