An Unprecedented Number of Cytochrome P450s Are Involved in Secondary Metabolism in

Mycobacterium Salinispora arenicola Streptomyces actinomycete biosynthetic gene clusters cytochrome P450 diversity genome-data mining marine natural products secondary metabolites

Journal

Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893

Informations de publication

Date de publication:
21 Apr 2022
Historique:
received: 04 04 2022
revised: 15 04 2022
accepted: 19 04 2022
entrez: 28 5 2022
pubmed: 29 5 2022
medline: 29 5 2022
Statut: epublish

Résumé

Cytochrome P450 monooxygenases (CYPs/P450s) are heme thiolate proteins present in species across the biological kingdoms. By virtue of their broad substrate promiscuity and regio- and stereo-selectivity, these enzymes enhance or attribute diversity to secondary metabolites. Actinomycetes species are well-known producers of secondary metabolites, especially

Identifiants

pubmed: 35630316
pii: microorganisms10050871
doi: 10.3390/microorganisms10050871
pmc: PMC9143469
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : University of Zululand, South Africa
ID : C686
Organisme : National Research Foundation (NRF), South Africa
ID : MND210615611861, MND210504599108, and MND190606443406
Organisme : National Science Centre (Poland)
ID : 2018/29/B/ST6/01989

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Auteurs

Nsikelelo Allison Malinga (NA)

Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.

Nomfundo Nzuza (N)

Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.

Tiara Padayachee (T)

Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.

Puleng Rosinah Syed (PR)

Department of Pharmaceutical Chemistry, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.

Rajshekhar Karpoormath (R)

Department of Pharmaceutical Chemistry, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.

Dominik Gront (D)

Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.

David R Nelson (DR)

Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Khajamohiddin Syed (K)

Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.

Classifications MeSH