Oral Administration of Valganciclovir Reduces Clinical Signs, Virus Shedding and Cell-Associated Viremia in Ponies Experimentally Infected with the Equid Herpesvirus-1 C
EHV-1
antiviral
equid alphaherpesvirus-1
experimental infection
ganciclovir
herpesvirus
pony
valganciclovir
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
04 May 2022
04 May 2022
Historique:
received:
24
03
2022
revised:
27
04
2022
accepted:
30
04
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Equid alphaherpesvirus-1 (EHV-1) is one of the main pathogens in horses, responsible for respiratory diseases, ocular diseases, abortions, neonatal foal death and neurological complications such as equine herpesvirus myeloencephalopathy (EHM). Current vaccines reduce the excretion and dissemination of the virus and, therefore, the extent of an epizooty. While their efficacy against EHV-1-induced abortion in pregnant mares and the decreased occurrence of an abortion storm in the field have been reported, their potential efficacy against the neurological form of disease remains undocumented. No antiviral treatment against EHV-1 is marketed and recommended to date. This study aimed to measure the protection induced by valganciclovir (VGCV), the prodrug of ganciclovir, in Welsh mountain ponies experimentally infected with an EHV-1 ORF30-C
Identifiants
pubmed: 35631060
pii: pathogens11050539
doi: 10.3390/pathogens11050539
pmc: PMC9148010
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Normandy County Council
ID : 17E01598/17EP04324
Organisme : Institut Français du Cheval et de l'Équitation
ID : 2017-008
Organisme : CENTAURE European project co-funded by Normandy County Council, European Union in the framework of the ERDF-ESF operational programme 2014-2020 and CENTAURE Scientific Groupement
ID : GIS19 LAB02
Organisme : Fonds Eperon
ID : OVERLORD N12-2017
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