Handgrip Strength Values Depend on Tumor Entity and Predict 180-Day Mortality in Malnourished Cancer Patients.
cancer
clinical outcomes
handgrip strength
malnutrition
nutritional support
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
23 May 2022
23 May 2022
Historique:
received:
21
04
2022
revised:
19
05
2022
accepted:
20
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Cancer-related malnutrition is a prevalent condition associated with a loss of muscle mass and impaired functional status, leading to immunodeficiency, impaired quality of life and adverse clinical outcomes. Handgrip strength (HGS) is a practical measure to assess muscle strength in individual patients during clinical practice. However, HGS reference values refer to populations of healthy people, and population-specific values, such as those in the population of cancer patients, still need to be defined. Within a secondary analysis of a previous randomized controlled nutritional trial focusing on hospitalized cancer patients at risk for malnutrition, we investigated sex-specific HGS values stratified by age and tumor entity. Additionally, we examined the association between HGS and 180-day all-cause mortality. We included data from 628 cancer patients, which were collected from eight hospitals in Switzerland. Depending on the age of patients, HGS varied among female patients from 7 kg to 26 kg and among male patients from 20.5 kg to 44 kg. An incremental decrease in handgrip strength by 10 kg resulted in a 50% increase in 180-day all-cause mortality (odds ratio 1.52 (95%CI 1.19 to 1.94), Our data provide evidence of the prognostic implications of HGS measurement in cancer patients and validate the prognostic value of handgrip strength in regard to long-term mortality. In addition, our results provide expected HGS values in the population of hospitalized malnourished cancer patients, which may allow better interpretation of values in individual patients.
Sections du résumé
BACKGROUND
BACKGROUND
Cancer-related malnutrition is a prevalent condition associated with a loss of muscle mass and impaired functional status, leading to immunodeficiency, impaired quality of life and adverse clinical outcomes. Handgrip strength (HGS) is a practical measure to assess muscle strength in individual patients during clinical practice. However, HGS reference values refer to populations of healthy people, and population-specific values, such as those in the population of cancer patients, still need to be defined.
METHODS
METHODS
Within a secondary analysis of a previous randomized controlled nutritional trial focusing on hospitalized cancer patients at risk for malnutrition, we investigated sex-specific HGS values stratified by age and tumor entity. Additionally, we examined the association between HGS and 180-day all-cause mortality.
RESULTS
RESULTS
We included data from 628 cancer patients, which were collected from eight hospitals in Switzerland. Depending on the age of patients, HGS varied among female patients from 7 kg to 26 kg and among male patients from 20.5 kg to 44 kg. An incremental decrease in handgrip strength by 10 kg resulted in a 50% increase in 180-day all-cause mortality (odds ratio 1.52 (95%CI 1.19 to 1.94),
CONCLUSION
CONCLUSIONS
Our data provide evidence of the prognostic implications of HGS measurement in cancer patients and validate the prognostic value of handgrip strength in regard to long-term mortality. In addition, our results provide expected HGS values in the population of hospitalized malnourished cancer patients, which may allow better interpretation of values in individual patients.
Identifiants
pubmed: 35631314
pii: nu14102173
doi: 10.3390/nu14102173
pmc: PMC9146854
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Swiss National Science Foundation
ID : PP00P3_150531, PP00P3_176972
Pays : Switzerland
Organisme : Research Council of the Kantonsspital Aarau, Switzerland
ID : 1410.000.058, 1410.000.044
Références
Ann Oncol. 2021 Nov;32(11):1451-1452
pubmed: 34428510
Curr Opin Clin Nutr Metab Care. 2015 Sep;18(5):465-70
pubmed: 26147527
J Cachexia Sarcopenia Muscle. 2016 Dec;7(5):535-546
pubmed: 27104109
Nestle Nutr Inst Workshop Ser. 2015;82:91-102
pubmed: 26544599
Oncotarget. 2017 Aug 10;8(45):79884-79896
pubmed: 29108370
Ann Oncol. 2021 Aug;32(8):1025-1033
pubmed: 34022376
Nutr Cancer. 2021;73(2):221-229
pubmed: 32286094
Clin Nutr. 2005 Apr;24(2):224-8
pubmed: 15784482
PLoS One. 2019 Jan 31;14(1):e0211452
pubmed: 30703162
Proc Nutr Soc. 2016 May;75(2):199-211
pubmed: 26786393
Nutrition. 2002 Jul-Aug;18(7-8):616-20
pubmed: 12093441
Swiss Med Wkly. 2014 Apr 29;144:w13957
pubmed: 24782139
Clin Nutr. 2021 Apr;40(4):1546-1554
pubmed: 33743290
PLoS One. 2016 Oct 4;11(10):e0163917
pubmed: 27701433
J Am Coll Cardiol. 2021 Aug 24;78(8):856-857
pubmed: 34412821
JPEN J Parenter Enteral Nutr. 2014 Feb;38(2):196-204
pubmed: 24748626
J Nutr Health Aging. 2018;22(10):1148-1161
pubmed: 30498820
Clin Nutr ESPEN. 2015 Jun;10(3):e89-e94
pubmed: 28531387
Health Rep. 2016 Oct 19;27(10):3-10
pubmed: 27759870
Clin Nutr. 2021 Apr;40(4):1843-1850
pubmed: 33081983
Aging Clin Exp Res. 2004 Feb;16(1):22-5
pubmed: 15132287
J Cachexia Sarcopenia Muscle. 2021 Feb;12(1):3-8
pubmed: 33382196
Nutr J. 2012 Apr 24;11:27
pubmed: 22531478
JAMA Netw Open. 2020 Mar 2;3(3):e200663
pubmed: 32154887
Clin Nutr. 2010 Feb;29(1):38-41
pubmed: 19573958
Clin Nutr. 2021 Mar;40(3):812-819
pubmed: 32919819
Clin Nutr. 2018 Feb;37(1):336-353
pubmed: 28802519
Age Ageing. 2019 Jan 1;48(1):16-31
pubmed: 30312372
Clin Nutr. 2011 Apr;30(2):135-42
pubmed: 21035927
Support Care Cancer. 2013 Dec;21(12):3261-70
pubmed: 23872952
Clin Nutr. 2019 Feb;38(1):1-9
pubmed: 30181091
Nutrition. 2015 Nov-Dec;31(11-12):1385-93
pubmed: 26429660
Clin Nutr ESPEN. 2017 Feb;17:28-32
pubmed: 28361744
Ageing Res Rev. 2019 May;51:48-54
pubmed: 30826500
Nutrition. 2021 Sep;89:111279
pubmed: 34090212
Am J Clin Nutr. 2021 Aug 2;114(2):731-740
pubmed: 33829236
Clin Nutr. 2003 Jun;22(3):321-36
pubmed: 12765673
Clin Nutr. 2009 Aug;28(4):455-60
pubmed: 19515464
Lancet. 2021 Nov 20;398(10314):1927-1938
pubmed: 34656286
Clin Nutr. 2020 Apr;39(4):1092-1100
pubmed: 31047715
J Hand Surg Eur Vol. 2009 Feb;34(1):76-84
pubmed: 19129352
Clin Nutr. 2020 Sep;39(9):2720-2729
pubmed: 31882232
Support Care Cancer. 2016 Jan;24(1):429-435
pubmed: 26099900
Clin Nutr. 2021 May;40(5):2762-2771
pubmed: 33933742
EClinicalMedicine. 2022 Feb 11;45:101301
pubmed: 35198927
N Engl J Med. 2014 Mar 27;370(13):1227-36
pubmed: 24670169
Lancet. 2019 Jun 8;393(10188):2312-2321
pubmed: 31030981