The Design and Synthesis of a New Series of 1,2,3-Triazole-Cored Structures Tethering Aryl Urea and Their Highly Selective Cytotoxicity toward HepG2.
1,2,3-triazole-containing drug
click reaction
drug discovery
hepatocellular carcinoma (HCC)
selective anti-HepG2 agent
sorafenib analog
targeted cancer drug
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
20 Apr 2022
20 Apr 2022
Historique:
received:
24
02
2022
revised:
15
04
2022
accepted:
16
04
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Target cancer drug therapy is an alternative treatment for advanced hepatocellular carcinoma (HCC) patients. However, the treatment using approved targeted drugs has encountered a number of limitations, including the poor pharmacological properties of drugs, therapy efficiency, adverse effects, and drug resistance. As a consequence, the discovery and development of anti-HCC drug structures are therefore still in high demand. Herein, we designed and synthesized a new series of 1,2,3-triazole-cored structures incorporating aryl urea as anti-HepG2 agents. Forty-nine analogs were prepared via nucleophilic addition and copper-catalyzed azide-alkyne cycloaddition (CuAAC) with excellent yields. Significantly, almost all triazole-cored analogs exhibited less cytotoxicity toward normal cells, human embryonal lung fibroblast cell MRC-5, compared to Sorafenib and Doxorubicin. Among them,
Identifiants
pubmed: 35631331
pii: ph15050504
doi: 10.3390/ph15050504
pmc: PMC9147274
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Thailand Research Fund
ID : MRG6180105
Organisme : Thailand Research Fund
ID : RTA6280004
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