Rapid Absorption of Naloxone from Eye Drops.
naloxone
ocular administration
opiate
pharmacokinetics
tolerability
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
25 Apr 2022
25 Apr 2022
Historique:
received:
01
04
2022
revised:
14
04
2022
accepted:
23
04
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Naloxone as emergency treatment for opioid overdosing can be administered via several routes. However, the available administration methods are invasive or may be associated with incomplete or slow naloxone absorption. We evaluated pharmacokinetics and local tolerance of naloxone ocular drops in healthy beagle dogs. Naloxone administration as eye drops produced fast absorption with time to maximum plasma concentration (t
Identifiants
pubmed: 35631356
pii: ph15050532
doi: 10.3390/ph15050532
pmc: PMC9143859
pii:
doi:
Types de publication
Journal Article
Langues
eng
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