Current Approaches to Monitor Macromolecules Directly from the Cerebral Interstitial Fluid.
cerebral open flow microperfusion
electrochemical biosensors
macromolecules
microdialysis
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
13 May 2022
13 May 2022
Historique:
received:
07
04
2022
revised:
07
05
2022
accepted:
11
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Gaining insights into the pharmacokinetic and pharmacodynamic properties of lead compounds is crucial during drug development processes. When it comes to the treatment of brain diseases, collecting information at the site of action is challenging. There are only a few techniques available that allow for the direct sampling from the cerebral interstitial space. This review concerns the applicability of microdialysis and other approaches, such as cerebral open flow microperfusion and electrochemical biosensors, to monitor macromolecules (neuropeptides, proteins, …) in the brain. Microdialysis and cerebral open flow microperfusion can also be used to locally apply molecules at the same time at the site of sampling. Innovations in the field are discussed, together with the pitfalls. Moreover, the 'nuts and bolts' of the techniques and the current research gaps are addressed. The implementation of these techniques could help to improve drug development of brain-targeted drugs.
Identifiants
pubmed: 35631637
pii: pharmaceutics14051051
doi: 10.3390/pharmaceutics14051051
pmc: PMC9146401
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Scientific Fund Willy Gepts of the UZ Brussel
ID : WFWG2021
Organisme : Research Foundation - Flanders
ID : S007918N
Organisme : Research Foundation - Flanders
ID : 1528219N
Organisme : Vrije Universiteit Brussel
ID : SRP49
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