Spontaneous DNA Synapsis by Forming Noncanonical Intermolecular Structures.
DNA-DNA junction
G-quadruplex
i-motif
recombination
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
23 May 2022
23 May 2022
Historique:
received:
18
04
2022
revised:
14
05
2022
accepted:
20
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
We report the spontaneous formation of DNA-DNA junctions in solution in the absence of proteins visualised using atomic force microscopy. The synapsis position fits with potential G-quadruplex (G4) sites. In contrast to the Holliday structure, these conjugates have an affinity for G4 antibodies. Molecular modelling was used to elucidate the possible G4/IM-synaptic complex structures. Our results indicate a new role of the intermolecular noncanonical structures in chromatin architecture and genomic rearrangement.
Identifiants
pubmed: 35632001
pii: polym14102118
doi: 10.3390/polym14102118
pmc: PMC9144187
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Russian Foundation for Basic Research
ID : 19-015-00024
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