A SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine Is Protective and Promotes a Strong Immunological Response in the Cynomolgus Macaque Coronavirus Disease 2019 (COVID-19) Model.

Army Liposomal Formulation QS-21 COVID-19 SARS-CoV-2 SpFN aluminum hydroxide ferritin nanoparticle primate vaccine

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
04 May 2022
Historique:
received: 12 04 2022
revised: 29 04 2022
accepted: 01 05 2022
entrez: 28 5 2022
pubmed: 29 5 2022
medline: 29 5 2022
Statut: epublish

Résumé

The COVID-19 pandemic has had a staggering impact on social, economic, and public health systems worldwide. Vaccine development and mobilization against SARS-CoV-2 (the etiologic agent of COVID-19) has been rapid. However, novel strategies are still necessary to slow the pandemic, and this includes new approaches to vaccine development and/or delivery that will improve vaccination compliance and demonstrate efficacy against emerging variants. Here, we report on the immunogenicity and efficacy of a SARS-CoV-2 vaccine comprising stabilized, pre-fusion spike protein trimers displayed on a ferritin nanoparticle (SpFN) adjuvanted with either conventional aluminum hydroxide or the Army Liposomal Formulation QS-21 (ALFQ) in a cynomolgus macaque COVID-19 model. Vaccination resulted in robust cell-mediated and humoral responses and a significant reduction in lung lesions following SARS-CoV-2 infection. The strength of the immune response suggests that dose sparing through reduced or single dosing in primates may be possible with this vaccine. Overall, the data support further evaluation of SpFN as a SARS-CoV-2 protein-based vaccine candidate with attention to fractional dosing and schedule optimization.

Identifiants

DOI: 10.3390/vaccines10050717 PMID: 35632473 PMC: PMC9145473
pubmed: 35632473
pii: vaccines10050717
doi: 10.3390/vaccines10050717
pmc: PMC9145473
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Sara C Johnston (SC)

Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

Keersten M Ricks (KM)

Diagnostic Systems Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

Ines Lakhal-Naouar (I)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Alexandra Jay (A)

Veterinary Medicine Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
ORCID: 0000-0002-5246-6940

Caroline Subra (C)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
ORCID: 0000-0001-5272-0972

Jo Lynne Raymond (JL)

Pathology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

Hannah A D King (HAD)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Franco Rossi (F)

Veterinary Medicine Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

Tamara L Clements (TL)

Diagnostic Systems Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

David Fetterer (D)

Veterinary Medicine Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

Samantha Tostenson (S)

Core Laboratory Services Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
ORCID: 0000-0002-6234-4891

Camila Macedo Cincotta (CM)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Holly R Hack (HR)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Caitlin Kuklis (C)

Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
ORCID: 0000-0002-9974-6640

Sandrine Soman (S)

Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Jocelyn King (J)

Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Kristina K Peachman (KK)

Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
ORCID: 0000-0001-8568-1439

Dohoon Kim (D)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Wei-Hung Chen (WH)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Rajeshwer S Sankhala (RS)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Elizabeth J Martinez (EJ)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
ORCID: 0000-0002-7755-7056

Agnes Hajduczki (A)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

William C Chang (WC)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
ORCID: 0000-0003-4967-6426

Misook Choe (M)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Paul V Thomas (PV)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Caroline E Peterson (CE)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
ORCID: 0000-0002-6087-7301

Alexander Anderson (A)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
ORCID: 0000-0002-0000-7734

Isabella Swafford (I)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Jeffrey R Currier (JR)

Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Dominic Paquin-Proulx (D)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
ORCID: 0000-0003-1407-3414

Linda L Jagodzinski (LL)

Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Gary R Matyas (GR)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
ORCID: 0000-0002-2074-2373

Mangala Rao (M)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Gregory D Gromowski (GD)

Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Sheila A Peel (SA)

Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Lauren White (L)

Veterinary Medicine Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

Jeffrey M Smith (JM)

Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

Jay W Hooper (JW)

Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

Nelson L Michael (NL)

Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
ORCID: 0000-0001-5882-5548

Kayvon Modjarrad (K)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

M Gordon Joyce (MG)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Aysegul Nalca (A)

Core Support Directorate, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
ORCID: 0000-0001-8581-7535

Diane L Bolton (DL)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Margaret L M Pitt (MLM)

Office of the Science Advisor, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
ORCID: 0000-0003-0080-3260

Classifications MeSH