Persistent Enterovirus Infection: Little Deletions, Long Infections.
cis-acting replication element
coxsackievirus B
enterovirus
negative-strand initiation
persistent infection
positive-strand initiation
terminal deletion
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
12 May 2022
12 May 2022
Historique:
received:
01
04
2022
revised:
04
05
2022
accepted:
10
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Enteroviruses have now been shown to persist in cell cultures and in vivo by a novel mechanism involving the deletion of varying amounts of the 5' terminal genomic region termed domain I (also known as the cloverleaf). Molecular clones of coxsackievirus B3 (CVB3) genomes with 5' terminal deletions (TD) of varying length allow the study of these mutant populations, which are able to replicate in the complete absence of wildtype virus genomes. The study of TD enteroviruses has revealed numerous significant differences from canonical enteroviral biology. The deletions appear and become the dominant population when an enterovirus replicates in quiescent cell populations, but can also occur if one of the cis-acting replication elements of the genome (CRE-2C) is artificially mutated in the element's stem and loop structures. This review discusses how the TD genomes arise, how they interact with the host, and their effects on host biology.
Identifiants
pubmed: 35632526
pii: vaccines10050770
doi: 10.3390/vaccines10050770
pmc: PMC9143164
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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