Evaluation methods of a rat sciatic nerve crush injury model.

Animals Crush Injuries Peripheral Nerve Injuries Rats Sciatic Nerve / injuries Sciatic Neuropathy
Neuroelectrophysiological Sciatic nerve crush injury

Journal

Journal of integrative neuroscience
ISSN: 0219-6352
Titre abrégé: J Integr Neurosci
Pays: Singapore
ID NLM: 101156357

Informations de publication

Date de publication:
11 May 2022
Historique:
received: 08 09 2021
revised: 30 12 2021
accepted: 07 01 2022
entrez: 28 5 2022
pubmed: 29 5 2022
medline: 1 6 2022
Statut: ppublish

Résumé

The rat sciatic nerve crush injury model is one of the most commonly used models to research peripheral nerve injury (PNI), however, the evaluation of the model preparation lacks exact standards. This study aimed to investigate accurately assessment methods for research concerning the rat sciatic nerve crush injury. The sciatic nerve crush injury model of was performed using the FST toothless forceps. The corresponding locations and pressures of different ratchet strengths were assessed by using CMAP, behavioral, and morphological methods. In each group of PNI, motor and sensory functions were gradually restricted on the injured side of rats as the applied pressure increased. CMAP was more sensitive to nerve injury arising out of the force values obtained from the forceps. As a sensitive indicator for PNI, the neuroelectrophysiological examination was more likely to reflect the morphological changes of injured nerves. These findings may provide a standardized approach to sciatic crush injury modelling.

Sections du résumé

BACKGROUND BACKGROUND
The rat sciatic nerve crush injury model is one of the most commonly used models to research peripheral nerve injury (PNI), however, the evaluation of the model preparation lacks exact standards. This study aimed to investigate accurately assessment methods for research concerning the rat sciatic nerve crush injury.
METHODS METHODS
The sciatic nerve crush injury model of was performed using the FST toothless forceps. The corresponding locations and pressures of different ratchet strengths were assessed by using CMAP, behavioral, and morphological methods.
RESULTS RESULTS
In each group of PNI, motor and sensory functions were gradually restricted on the injured side of rats as the applied pressure increased. CMAP was more sensitive to nerve injury arising out of the force values obtained from the forceps.
CONCLUSIONS CONCLUSIONS
As a sensitive indicator for PNI, the neuroelectrophysiological examination was more likely to reflect the morphological changes of injured nerves. These findings may provide a standardized approach to sciatic crush injury modelling.

Identifiants

DOI: 10.31083/j.jin2103091 PMID: 35633172
pubmed: 35633172
pii: S0219-6352(22)00357-6
doi: 10.31083/j.jin2103091
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

91

Informations de copyright

© 2022 The Author(s). Published by IMR Press.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Auteurs

Yun An (Y)

Department of Tuina, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 200437 Shanghai, China.

Hui-Xin Yan (HX)

Department of Tuina, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 200437 Shanghai, China.

Jiang-Na Zhao (JN)

Department of Tuina, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 200437 Shanghai, China.

Xu-Ming Yang (XM)

Acupuncture and Tuina College, Shanghai University of Traditional Chinese Medicine, 201023 Shanghai, China.

Jun-Tao Yan (JT)

Department of Tuina, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 200437 Shanghai, China.

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Classifications MeSH

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questionsmedicales.fr › Plaies et blessures › Lésions d'écrasement › Evaluation methods of a rat sciatic nerve...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Lésions des nerfs périphériques › Evaluation methods of a rat sciatic nerve...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Evaluation methods of a rat sciatic nerve...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs spinaux › Plexus lombosacral › Nerf ischiatique › Evaluation methods of a rat sciatic nerve...
questionsmedicales.fr › Maladies du système nerveux › Maladies neuromusculaires › Neuropathies périphériques › Mononeuropathies › Neuropathie du nerf sciatique › Evaluation methods of a rat sciatic nerve...