Polypharmacy and Mental Health Issues in the Senior Hemodialysis Patient.
chronic kidney failure
hemodialysis
mental health
pharmacokinetics
polypharmacy
psychotropic medications
seniors
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
02
2022
accepted:
25
04
2022
entrez:
31
5
2022
pubmed:
1
6
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Hemodialysis (HD) is the most common method of chronic kidney failure (CKF) treatment, with 65% of European patients with CKF receiving HD in 2018. Regular two to three HD sessions weekly severely lower their quality of life, resulting in a higher incidence of depression and anxiety, which is present in one third to one half of these patients. Additionally, the age of patients receiving HD is increasing with better treatment and care, resulting in more cognitive impairment being uncovered. Lastly, patients with other mental health issues can also develop CKF during their life with need for kidney replacement therapy (KRT). All these conditions need to receive adequate care, which often means prescribing psychotropic medications. Importantly, many of these drugs are eliminated through the kidneys, which results in altered pharmacokinetics when patients receive KRT. This narrative review will focus on common issues and medications of CKF patients, their comorbidities, mental health issues, use of psychotropic medications and their altered pharmacokinetics when used in HD, polypharmacy, and drug interactions, as well as deprescribing algorithms developed for these patients.
Identifiants
pubmed: 35633796
doi: 10.3389/fpsyt.2022.882860
pmc: PMC9133494
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
882860Informations de copyright
Copyright © 2022 Knehtl, Petreski, Piko, Ekart and Bevc.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Alzheimers Dis. 2014;41(2):615-31
pubmed: 24662102
Nephrol Dial Transplant. 2012 Oct;27(10):3736-45
pubmed: 22859791
BMC Health Serv Res. 2016 Sep 08;16:482
pubmed: 27608830
Pharmacoepidemiol Drug Saf. 2011 Feb;20(2):177-84
pubmed: 21254289
J Am Soc Nephrol. 2019 Jan;30(1):147-158
pubmed: 30530658
J Clin Pharm Ther. 2017 Apr;42(2):195-200
pubmed: 28155237
Can J Kidney Health Dis. 2020 Oct 29;7:2054358120968674
pubmed: 33194213
J Am Soc Nephrol. 2018 Apr;29(4):1317-1325
pubmed: 29496888
Braz J Psychiatry. 2019 Mar 07;41(5):441-446
pubmed: 30843961
Curr Psychiatry Rep. 2012 Aug;14(4):376-90
pubmed: 22707017
Psychopharmacology (Berl). 2021 Feb;238(2):329-340
pubmed: 33410987
Int Clin Psychopharmacol. 2018 Mar;33(2):103-110
pubmed: 29112517
Pharmacopsychiatry. 2008 Nov;41(6):259-60
pubmed: 19067265
Age Ageing. 2020 Jul 1;49(4):605-614
pubmed: 32484850
J Psychopharmacol. 2019 Aug;33(8):986-993
pubmed: 31084455
Neuropharmacology. 2020 Sep 15;175:108181
pubmed: 32533978
J Am Geriatr Soc. 2015 Dec;63(12):2643-2644
pubmed: 26691710
Nervenarzt. 2021 May;92(5):487-493
pubmed: 32986155
Nephron Extra. 2013 Jun 08;3(1):59-65
pubmed: 23898347
Clin Pharmacol Ther. 2020 Oct;108(4):866-873
pubmed: 32356565
Expert Opin Drug Saf. 2020 Dec;19(12):1529-1538
pubmed: 33064050
Pharmacy (Basel). 2018 Jul 25;6(3):
pubmed: 30046021
Clin Interv Aging. 2016 Jun 23;11:857-66
pubmed: 27382268
Psychiatr Prax. 2013 Apr;40(3):154-8
pubmed: 23345188
Arch Gen Psychiatry. 2010 Jan;67(1):26-36
pubmed: 20048220
Rev Assoc Med Bras (1992). 2020 Jul;66(7):918-923
pubmed: 32844941
Ther Drug Monit. 2005 Oct;27(5):558-61
pubmed: 16175125
Nephrology (Carlton). 2021 Nov;26(11):890-897
pubmed: 34240512
Clin Drug Investig. 2012 Aug 1;32(8):539-45
pubmed: 22715858
Age Ageing. 2015 Mar;44(2):213-8
pubmed: 25324330
Semin Dial. 2015 Jul-Aug;28(4):427-32
pubmed: 25864928
Pharmacoepidemiol Drug Saf. 2017 Nov;26(11):1387-1394
pubmed: 28665012
Sci Rep. 2019 Jul 2;9(1):9563
pubmed: 31266990
J Clin Psychopharmacol. 2020 Mar/Apr;40(2):200-202
pubmed: 32134859
Int J Pharm Pract. 2020 Dec;28(6):635-642
pubmed: 33094884
Case Rep Nephrol Dial. 2019 Sep 5;9(3):126-136
pubmed: 31616673
Expert Opin Drug Metab Toxicol. 2019 Oct;15(10):831-847
pubmed: 31526279
Psychiatr Danub. 2018 Jun;30(Suppl 4):169-171
pubmed: 29864754
Expert Opin Drug Metab Toxicol. 2016;12(4):407-22
pubmed: 26878495
BMJ. 2021 Jul 13;374:n1585
pubmed: 34257088
Nihon Shinkei Seishin Yakurigaku Zasshi. 1998 Apr;18(2):45-7
pubmed: 9656232
CMAJ. 2019 Sep 16;191(37):E1018-E1024
pubmed: 31527187
Aust Prescr. 2020 Apr;43(2):57-60
pubmed: 32346212
Drugs Aging. 2018 Nov;35(11):973-984
pubmed: 30284120
Asian J Psychiatr. 2018 Jan;31:90-91
pubmed: 29453148
J Clin Psychopharmacol. 2003 Jun;23(3):314
pubmed: 12826994
Med J Aust. 2019 Mar;210(4):174-179
pubmed: 30771226
Biomed Res Int. 2013;2013:458989
pubmed: 24089679
Clin Pharmacokinet. 2018 Dec;57(12):1493-1528
pubmed: 29915922
Med Clin North Am. 2020 Sep;104(5):751-765
pubmed: 32773043
J Pharmacol Sci. 2012;119(4):324-9
pubmed: 22863669
J Am Geriatr Soc. 2019 Apr;67(4):674-694
pubmed: 30693946
Ann Clin Psychiatry. 2019 May;31(2):144-152
pubmed: 31046036
J Neural Transm (Vienna). 2021 Feb;128(2):243-252
pubmed: 33417009
Alzheimers Dement (N Y). 2019 Sep 03;5:431-440
pubmed: 31517030
Expert Rev Clin Pharmacol. 2020 Jan;13(1):15-22
pubmed: 31790317
Drugs Real World Outcomes. 2019 Jun;6(2):73-82
pubmed: 31020617
Asian J Psychiatr. 2021 Jan;55:102484
pubmed: 33341539
J Clin Epidemiol. 1992 Oct;45(10):1045-51
pubmed: 1474400
Psychiatry Clin Neurosci. 2013 Feb;67(2):126
pubmed: 23438167
Soc Psychiatry Psychiatr Epidemiol. 2020 Feb;55(2):165-173
pubmed: 31630215
Psychiatry Res. 2020 Nov;293:113409
pubmed: 32829072
Clin J Am Soc Nephrol. 2020 Dec 31;16(1):144-146
pubmed: 32792413
Expert Opin Drug Saf. 2018 Jan;17(1):51-54
pubmed: 29082802
Cochrane Database Syst Rev. 2018 Jun 18;6:CD001190
pubmed: 29923184
Neurodegener Dis Manag. 2021 Feb;11(1):35-48
pubmed: 33198569
Ther Drug Monit. 2009 Jun;31(3):281-2
pubmed: 19363462
Clin Interv Aging. 2014 Aug 16;9:1363-73
pubmed: 25170260
Neurotherapeutics. 2019 Jul;16(3):666-674
pubmed: 31376068
Eur J Clin Pharmacol. 2015 Jul;71(7):861-75
pubmed: 25967540
R I Med J (2013). 2016 Jul 01;99(7):15-8
pubmed: 27379352
Cochrane Database Syst Rev. 2015 Jan 16;1:CD009831
pubmed: 25592299
Neurology. 2006 Jul 25;67(2):216-23
pubmed: 16864811
Can Fam Physician. 2018 May;64(5):339-351
pubmed: 29760253
Expert Opin Drug Saf. 2020 Aug;19(8):981-998
pubmed: 32657173
Am J Geriatr Psychiatry. 2009 Feb;17(2):170-3
pubmed: 19155749
Ment Health Clin. 2019 Nov 27;9(6):404-407
pubmed: 31857937
Psychol Health Med. 2018 Oct;23(9):1069-1078
pubmed: 29706105
Ther Adv Cardiovasc Dis. 2021 Jan-Dec;15:17539447211058892
pubmed: 34841978
J Gen Intern Med. 2020 Nov;35(11):3323-3332
pubmed: 32820421
Curr Clin Pharmacol. 2010 May;5(2):115-24
pubmed: 20156150
Am J Kidney Dis. 2019 Dec;74(6):782-790
pubmed: 31378643
Clin Nephrol. 1995 Aug;44(2):121-4
pubmed: 8529300
Pharmacoepidemiol Drug Saf. 2021 Sep;30(9):1258-1268
pubmed: 34146372
Am J Geriatr Pharmacother. 2012 Apr;10(2):139-50
pubmed: 22285509
JAMA. 2017 May 23;317(20):2114-2122
pubmed: 28535241
Eur Geriatr Med. 2020 Dec;11(6):1035-1041
pubmed: 32772258
J Am Soc Nephrol. 2017 Aug;28(8):2511-2520
pubmed: 28270412
Can Fam Physician. 2018 Jan;64(1):17-27
pubmed: 29358245