Pluripotent stem cell assays: Modalities and applications for predictive developmental toxicity.
Developmental toxicity
Embryonic stem cell test
Predictive toxicology
Teratogenesis
Journal
Current research in toxicology
ISSN: 2666-027X
Titre abrégé: Curr Res Toxicol
Pays: Netherlands
ID NLM: 101771915
Informations de publication
Date de publication:
2022
2022
Historique:
received:
07
02
2022
revised:
21
04
2022
accepted:
09
05
2022
entrez:
31
5
2022
pubmed:
1
6
2022
medline:
1
6
2022
Statut:
epublish
Résumé
This manuscript provides a review focused on embryonic stem cell-based models and their place within the landscape of alternative developmental toxicity assays. Against the background of the principles of developmental toxicology, the wide diversity of alternative methods using pluripotent stem cells developed in this area over the past half century is reviewed. In order to provide an overview of available models, a systematic scoping review was conducted following a published protocol with inclusion criteria, which were applied to select the assays. Critical aspects including biological domain, readout endpoint, availability of standardized protocols, chemical domain, reproducibility and predictive power of each assay are described in detail, in order to review the applicability and limitations of the platform in general and progress moving forward to implementation. The horizon of innovative routes of promoting regulatory implementation of alternative methods is scanned, and recommendations for further work are given.
Identifiants
pubmed: 35633891
doi: 10.1016/j.crtox.2022.100074
pii: S2666-027X(22)00011-1
pmc: PMC9130094
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100074Informations de copyright
© 2022 Published by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: T.B.K. is Editor in Chief of Current Research in Toxicology. G.P.D., K.T., and H.K. are founding members of the journal’s editorial board. These individuals were not involved in the editorial process or peer review evaluation of the submission. The authors declare that they have no other known competing financial interests that could have appeared to influence the work reported in this paper.
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