Antiviral Activities of Interleukin-27: A Partner for Interferons?
antiviral immunity
infection
interferons
interleukin-27
viral immunology
virus
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
03
2022
accepted:
14
04
2022
entrez:
31
5
2022
pubmed:
1
6
2022
medline:
3
6
2022
Statut:
epublish
Résumé
Emergence of new, pandemic-level viral threats has brought to the forefront the importance of viral immunology and continued improvement of antiviral therapies. Interleukin-27 (IL-27) is a pleiotropic cytokine that regulates both innate and adaptive immune responses. Accumulating evidence has revealed potent antiviral activities of IL-27 against numerous viruses, including HIV, influenza, HBV and more. IL-27 contributes to the immune response against viruses indirectly by increasing production of interferons (IFNs) which have various antiviral effects. Additionally, IL-27 can directly interfere with viral infection both by acting similarly to an IFN itself and by modulating the differentiation and function of various immune cells. This review discusses the IFN-dependent and IFN-independent antiviral mechanisms of IL-27 and highlights the potential of IL-27 as a therapeutic cytokine for viral infection.
Identifiants
pubmed: 35634328
doi: 10.3389/fimmu.2022.902853
pmc: PMC9134790
doi:
Substances chimiques
Antiviral Agents
0
Cytokines
0
Interleukin-27
0
Interferons
9008-11-1
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
902853Informations de copyright
Copyright © 2022 Amsden, Kourko, Roth and Gee.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cancer Res. 2018 Jan 1;78(1):182-194
pubmed: 29093008
PLoS Pathog. 2017 Nov 29;13(11):e1006738
pubmed: 29186193
Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18535-40
pubmed: 23091017
Curr Opin Virol. 2011 Dec;1(6):519-25
pubmed: 22328912
PLoS Pathog. 2015 May 08;11(5):e1004881
pubmed: 25955717
Immunity. 2002 Jun;16(6):779-90
pubmed: 12121660
J Virol. 2017 Jul 27;91(16):
pubmed: 28592538
J Interferon Cytokine Res. 2016 Nov;36(11):617-629
pubmed: 27617644
PLoS Pathog. 2013;9(11):e1003735
pubmed: 24244162
Sci Adv. 2020 Apr 01;6(14):eaay3245
pubmed: 32270034
Nat Immunol. 2011 Apr;12(4):327-34
pubmed: 21297642
Eur J Immunol. 2016 Dec;46(12):2778-2788
pubmed: 27701741
J Immunol. 2005 Aug 1;175(3):1686-93
pubmed: 16034109
J Viral Hepat. 2011 Aug;18(8):549-61
pubmed: 20626625
Front Oncol. 2019 Oct 01;9:969
pubmed: 31681561
J Immunol. 2014 Jul 1;193(1):285-94
pubmed: 24890725
J Virol. 2018 May 29;92(12):
pubmed: 29593047
Blood. 2007 Mar 1;109(5):1841-9
pubmed: 17068156
AIDS. 2019 Oct 1;33(12):1819-1830
pubmed: 31274540
Hepatology. 2009 Aug;50(2):585-91
pubmed: 19582813
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15047-52
pubmed: 14657353
Immunity. 2015 May 19;42(5):877-89
pubmed: 25992861
J Immunol. 2008 May 1;180(9):6325-33
pubmed: 18424756
Int J Mol Sci. 2017 Apr 28;18(5):
pubmed: 28452924
Immunity. 2013 Sep 19;39(3):548-59
pubmed: 23993651
Science. 1993 Apr 16;260(5106):355-8
pubmed: 7682337
Cytokine. 2013 Feb;61(2):485-90
pubmed: 23280240
Nat Rev Immunol. 2002 Sep;2(9):675-87
pubmed: 12209136
PLoS Pathog. 2017 Jan 27;13(1):e1006173
pubmed: 28129374
Microb Pathog. 2020 Feb;139:103919
pubmed: 31830579
J Biol Chem. 2012 Apr 6;287(15):11899-910
pubmed: 22343630
J Immunol. 2021 Jul 15;207(2):577-589
pubmed: 34145061
J Immunol. 2009 May 1;182(9):5748-56
pubmed: 19380822
J Immunol. 2011 Sep 15;187(6):3145-54
pubmed: 21844390
J Clin Cell Immunol. 2015 Apr;6(2):
pubmed: 26213635
J Innate Immun. 2021;13(6):345-358
pubmed: 34058746
J Exp Med. 2013 Mar 11;210(3):517-34
pubmed: 23460728
J Biol Chem. 2018 Nov 9;293(45):17631-17645
pubmed: 30242126
AIDS. 2010 Jun 1;24(9):1371-4
pubmed: 20375875
PLoS One. 2012;7(9):e45706
pubmed: 23049843
Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2992-7
pubmed: 15710891
Nat Med. 2009 Mar;15(3):277-84
pubmed: 19234462
Front Immunol. 2018 Oct 16;9:2379
pubmed: 30459758
Sci Rep. 2012;2:974
pubmed: 23240078
PLoS Pathog. 2016 Dec 7;12(12):e1006050
pubmed: 27926930
Nat Commun. 2019 Oct 11;10(1):4670
pubmed: 31604943
J Immunother Cancer. 2019 Jul 5;7(1):168
pubmed: 31277710
Cell Mol Immunol. 2018 Mar;15(3):272-281
pubmed: 28194021
Mol Cells. 2014 Apr;37(4):275-85
pubmed: 24625576
Biochim Biophys Acta Mol Cell Res. 2017 Mar;1864(3):516-526
pubmed: 27939431
Blood. 2009 Aug 27;114(9):1864-74
pubmed: 19556424
Trends Microbiol. 2007 Apr;15(4):143-6
pubmed: 17336072
Sci Rep. 2019 Mar 21;9(1):4984
pubmed: 30899058
J Virol. 2013 Oct;87(20):11244-54
pubmed: 23946454
Trends Immunol. 2013 Feb;34(2):81-9
pubmed: 23000011
J Immunol. 2016 Sep 15;197(6):2369-81
pubmed: 27527594
EBioMedicine. 2020 Apr;54:102734
pubmed: 32279057
Biochem Biophys Res Commun. 2013 May 3;434(2):228-34
pubmed: 23535375
Nature. 1990 Oct 18;347(6294):669-71
pubmed: 1699135
J Immunol. 2008 Jan 15;180(2):693-7
pubmed: 18178806
J Leukoc Biol. 2017 Sep;102(3):925-939
pubmed: 28698313
J Virol. 2014 Aug;88(16):9245-59
pubmed: 24899179
Front Immunol. 2016 Nov 11;7:498
pubmed: 27891131
Viruses. 2019 Aug 22;11(9):
pubmed: 31443406
Clin Exp Immunol. 2010 Sep;161(3):397-406
pubmed: 20560984
J Leukoc Biol. 2007 Nov;82(5):1185-92
pubmed: 17684041
Cell Host Microbe. 2008 Nov 13;4(5):470-83
pubmed: 18996347
Eur J Immunol. 2007 Dec;37(12):3499-508
pubmed: 17985330
J Immunol. 2014 Jan 15;192(2):691-703
pubmed: 24337382
Front Immunol. 2018 Sep 11;9:2061
pubmed: 30254639
J Virol. 2010 Oct;84(20):10802-11
pubmed: 20686034
Microbiol Mol Biol Rev. 2012 Mar;76(1):16-32
pubmed: 22390970
J Biol Chem. 2005 Sep 2;280(35):30838-44
pubmed: 15998638
Cytokine. 2017 Jan;89:194-200
pubmed: 26868086
Cytokine Growth Factor Rev. 2013 Dec;24(6):571-7
pubmed: 23962745
PLoS Pathog. 2017 Sep 27;13(9):e1006640
pubmed: 28953978
Cell Immunol. 2021 Sep;367:104411
pubmed: 34325085
Annu Rev Virol. 2019 Sep 29;6(1):567-584
pubmed: 31283436
J Virol. 2007 Sep;81(17):8953-66
pubmed: 17567694
Eur J Immunol. 2011 Jan;41(1):47-59
pubmed: 21182076
Eur J Immunol. 2006 Aug;36(8):2046-60
pubmed: 16856207
J Exp Med. 2005 Mar 21;201(6):1007-18
pubmed: 15767367
J Interferon Cytokine Res. 2010 Jun;30(6):427-31
pubmed: 20235668
Immunobiology. 2013 Apr;218(4):628-34
pubmed: 22925810
J Immunol. 2009 Dec 15;183(12):7692-702
pubmed: 19933857
Am J Pathol. 2014 Jun;184(6):1807-18
pubmed: 24726498
AIDS. 2008 Jan 2;22(1):39-45
pubmed: 18090390
J Immunol Res. 2017;2017:6104054
pubmed: 28316998
Front Microbiol. 2019 May 10;10:1057
pubmed: 31134045
Biotechnol Bioeng. 2017 Oct;114(10):2289-2297
pubmed: 28498621
Eur J Immunol. 2015 Jan;45(1):192-202
pubmed: 25308526
Cell Mol Immunol. 2016 Jan;13(1):3-10
pubmed: 26189369
Traffic. 2002 Oct;3(10):710-7
pubmed: 12230469
Nature. 2000 Oct 19;407(6806):916-20
pubmed: 11057672
J Virol. 2017 May 12;91(11):
pubmed: 28331088
Viruses. 2011 Jun;3(6):920-40
pubmed: 21994762
J Virol. 2004 Sep;78(17):9093-104
pubmed: 15308705
Immunity. 2019 Jan 15;50(1):37-50
pubmed: 30650380
J Leukoc Biol. 2017 Jul;102(1):83-94
pubmed: 28377398
PLoS One. 2013;8(3):e59194
pubmed: 23527130
PLoS One. 2014 Jun 04;9(6):e98989
pubmed: 24896094
Sci Rep. 2018 Sep 12;8(1):13704
pubmed: 30209294
PLoS Pathog. 2014 May 08;10(5):e1004110
pubmed: 24809349
J Immunol. 2004 Feb 15;172(4):2225-31
pubmed: 14764690
J Immunol. 2012 Jan 15;188(2):864-73
pubmed: 22156348
Curr HIV Res. 2017;15(4):279-284
pubmed: 28521720
iScience. 2021 Dec 09;25(1):103588
pubmed: 35005538