Looking ahead: giant-cell arteritis in 10 years time.
biomarkers
future
giant-cell arteritis
imaging
treatment
Journal
Therapeutic advances in musculoskeletal disease
ISSN: 1759-720X
Titre abrégé: Ther Adv Musculoskelet Dis
Pays: England
ID NLM: 101517322
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
12
2021
accepted:
01
04
2022
entrez:
31
5
2022
pubmed:
1
6
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Although great improvements have been achieved in the fields of diagnosing and treating patients with giant-cell arteritis (GCA) in the last decades, several questions remain unanswered. The progressive increase in the number of older people, together with growing awareness of the disease and use of advanced diagnostic tools by healthcare professionals, foretells a possible increase in both prevalence and number of newly diagnosed patients with GCA in the coming years. A thorough clarification of pathogenetic mechanisms and a better definition of clinical subsets are the first steps toward a better understanding of the disease and, subsequently, toward a better use of existing and future therapeutic options. Examination of the role of different imaging techniques for GCA diagnosing and monitoring, optimization, and personalization of glucocorticoids and other immunosuppressive agents, further development and introduction of novel drugs, identification of prognostic factors for long-term outcomes and management of treatment discontinuation will be the central topics of the research agenda in years to come.
Identifiants
pubmed: 35634351
doi: 10.1177/1759720X221096366
pii: 10.1177_1759720X221096366
pmc: PMC9136445
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1759720X221096366Informations de copyright
© The Author(s), 2022.
Déclaration de conflit d'intérêts
Conflict of interest statement: The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: FB reported receiving consultancy fees, honoraria, and travel expenses from Horizon Pharma, Roche, Sanofi and Galapagos. He served as principal investigator and site investigator in GCA and PMR trials (Sanofi). CD has received consulting/speaker’s fees from Abbvie, Eli Lilly, Janssen, Novartis, Pfizer, Roche, Galapagos, and Sanofi. ELM has received consulting/speaker’s fees from Boehringer Ingelheim and Gilead, editorial royalties from UpToDate, Data Safety Monitoring Board for Horizon Pharmaceuticals
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