Limonin Isolated From Pomelo Seed Antagonizes Aβ25-35-Mediated Neuron Injury via PI3K/AKT Signaling Pathway by Regulating Cell Apoptosis.
PC12 cells
PI3K/AKT
limonin
neuroprotective activity
pomelo seed
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2022
2022
Historique:
received:
18
02
2022
accepted:
15
04
2022
entrez:
31
5
2022
pubmed:
1
6
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Pomelo seed as a by-product from pomelo consumption is rich in bioactive compounds, however, a huge volume of pomelo seed was disposed as wastes, the comprehensive utilization of pomelo seed could not only generate valued-added products/ingredients, but also decrease the environmental pollution. In this study, the main active substance limonin in pomelo seed was considered as a high-value bioactive compound. The purification of limonin from pomelo seed was investigated, and the neuroprotective and mechanism were characterized. The UPLC-MS/MS results indicated that 29 compounds in pomelo seed were identified, including 14 flavonoids, 3 limonids, 9 phenols and 3 coumarins. Moreover, high purity of limonin was obtained by crystallization and preparative-HPLC. Furthermore, limonin pretreatment can antagonize the cell damage mediated by Aβ
Identifiants
pubmed: 35634407
doi: 10.3389/fnut.2022.879028
pmc: PMC9133815
doi:
Types de publication
Journal Article
Langues
eng
Pagination
879028Informations de copyright
Copyright © 2022 Qiu, Yang, Ma, Song and Liu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Appl Microbiol Biotechnol. 2014 Jun;98(11):5153-60
pubmed: 24652061
Acta Neuropathol. 2019 Apr;137(4):557-569
pubmed: 30712078
Bioorg Med Chem. 2011 Jul 1;19(13):4021-7
pubmed: 21652214
Biochim Biophys Acta Mol Cell Res. 2021 May;1868(6):118997
pubmed: 33711363
Nat Neurosci. 2010 Jul;13(7):812-8
pubmed: 20581818
Chem Sci. 2020 Sep 8;11(37):10243-10254
pubmed: 34094290
Biosci Biotechnol Biochem. 2020 Nov;84(11):2273-2280
pubmed: 32713252
J Funct Foods. 2020 Dec;75:104243
pubmed: 33072190
J Neural Transm Suppl. 1994;44:29-45
pubmed: 7897398
Fitoterapia. 2020 Apr;142:104503
pubmed: 32061909
Cell Calcium. 2016 May;59(5):240-50
pubmed: 26971122
Comput Struct Biotechnol J. 2019 Apr 22;17:579-590
pubmed: 31073393
Int J Mol Sci. 2018 Jul 20;19(7):
pubmed: 30036972
Bioorg Med Chem Lett. 2013 Mar 1;23(5):1232-7
pubmed: 23380377
J Nat Prod. 2008 Feb;71(2):208-11
pubmed: 18198838
J Mol Neurosci. 2010 Sep;42(1):9-16
pubmed: 20155333
Biomed Res Int. 2020 Apr 27;2020:8210578
pubmed: 32420373
Cell. 1995 Jan 27;80(2):285-91
pubmed: 7834748
Molecules. 2019 Oct 12;24(20):
pubmed: 31614806
Mol Biol Rep. 2020 Dec;47(12):9553-9566
pubmed: 33211296
Front Mol Neurosci. 2019 Aug 16;12:192
pubmed: 31474828
Food Chem. 2021 Jul 30;351:129247
pubmed: 33640768
Biochem Biophys Res Commun. 2019 Oct 20;518(3):438-444
pubmed: 31447119
J Agric Food Chem. 2014 May 21;62(20):4643-51
pubmed: 24802243
Chem Soc Rev. 2017 Jan 23;46(2):310-323
pubmed: 27878186
J Biol Chem. 2011 May 27;286(21):18414-25
pubmed: 21460223
J Biol Chem. 2021 Jul;297(1):100845
pubmed: 34052228
Ann Transl Med. 2020 Sep;8(18):1172
pubmed: 33241021
PLoS One. 2017 Feb 16;12(2):e0172085
pubmed: 28208159
Neurochem Int. 2021 Mar;144:104931
pubmed: 33276023
J Agric Food Chem. 2006 May 31;54(11):3827-31
pubmed: 16719503
Food Funct. 2020 Mar 26;11(3):2427-2438
pubmed: 32129354