Toward Composite Pain Biomarkers of Neuropathic Pain-Focus on Peripheral Neuropathic Pain.
biomarker
endocannabinoid
inflammation
neuropathic
opiate
pain
Journal
Frontiers in pain research (Lausanne, Switzerland)
ISSN: 2673-561X
Titre abrégé: Front Pain Res (Lausanne)
Pays: Switzerland
ID NLM: 9918227269806676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
04
02
2022
accepted:
21
04
2022
entrez:
31
5
2022
pubmed:
1
6
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Chronic pain affects ~10-20% of the U.S. population with an estimated annual cost of $600 billion, the most significant economic cost of any disease to-date. Neuropathic pain is a type of chronic pain that is particularly difficult to manage and leads to significant disability and poor quality of life. Pain biomarkers offer the possibility to develop objective pain-related indicators that may help diagnose, treat, and improve the understanding of neuropathic pain pathophysiology. We review neuropathic pain mechanisms related to opiates, inflammation, and endocannabinoids with the objective of identifying composite biomarkers of neuropathic pain. In the literature, pain biomarkers typically are divided into physiological non-imaging pain biomarkers and brain imaging pain biomarkers. We review both types of biomarker types with the goal of identifying composite pain biomarkers that may improve recognition and treatment of neuropathic pain.
Identifiants
pubmed: 35634449
doi: 10.3389/fpain.2022.869215
pmc: PMC9130475
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
869215Informations de copyright
Copyright © 2022 Diaz, Caylor, Strigo, Lerman, Henry, Lopez, Wallace, Ellis, Simmons and Keltner.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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