Clinical Significances of Anti-Collagen Type I and Type III Antibodies in Antibody-Mediated Rejection.
antibody-mediated rejection
graft failure
kidney
kidney transplantation
non-HLA antibody
Journal
Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277
Titre abrégé: Transpl Int
Pays: Switzerland
ID NLM: 8908516
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
10
2021
accepted:
13
04
2022
entrez:
31
5
2022
pubmed:
1
6
2022
medline:
3
6
2022
Statut:
epublish
Résumé
It is important to determine the clinical significance of non-human leukocyte antigen (HLA) antibodies and their association with antibody-mediated rejection (ABMR) of kidney allografts. We collected post-transplant sera from 68 ABMR patients, 67 T-cell mediated rejection (TCMR) patients, and 83 control subjects without rejection, and determined the titers of 39 non-HLA antibodies including antibodies for angiotensin II receptor type I and MICA. We compared all these non-HLA antibody titers among the study groups. Then, we investigated their association with the risk of death-censored graft failure in ABMR cases. Among the antibodies evaluated, anti-collagen type I (
Identifiants
pubmed: 35634584
doi: 10.3389/ti.2022.10099
pii: 10099
pmc: PMC9131656
doi:
Substances chimiques
Antibodies
0
Collagen Type I
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
10099Informations de copyright
Copyright © 2022 Park, Yang, Kim, Cho, Yang, Min, Ha, Jeong, Bhoo, Kim, Kim, Oh, Joo, Kim, Moon, Song and Lee.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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