Cumulative Genetic Score of DRD2 Polymorphisms Is Associated with Impulsivity and Masked Semantic Priming.
DRD2
Dopamine
Executive functions
Impulsivity
Semantic priming
Journal
Journal of molecular neuroscience : MN
ISSN: 1559-1166
Titre abrégé: J Mol Neurosci
Pays: United States
ID NLM: 9002991
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
31
03
2022
accepted:
04
05
2022
pubmed:
1
6
2022
medline:
17
8
2022
entrez:
31
5
2022
Statut:
ppublish
Résumé
Individual differences in the magnitude of semantic priming effects are associated with executive functions (EF). Striatal dopamine has been shown to be associated with EF as well as impulsivity and could therefore be associated with differences in the magnitude of semantic priming. We investigated n = 155 individuals in an unmasked as well as in a masked semantic priming paradigm. We additionally assessed self-reported impulsivity and a cumulative genetic score (CGS) comprising six polymorphisms that have been found to be functionally relevant for the expression of the DRD2 gene. We found a significantly negative association between the DRD2 CGS and reaction time priming in the masked semantic priming paradigm. In addition, the DRD2 CGS was positively associated with self-reported impulsivity. Our findings complement previous research by showing a role of the DRD2 gene for masked semantic priming. Therefore, the investigation of genes within the dopamine system might improve our understanding of the genetic basis of impulsivity and semantic processing. Thus, the DRD2 CGS is of interest for clinical as well as experimental psychological research.
Identifiants
pubmed: 35635675
doi: 10.1007/s12031-022-02019-5
pii: 10.1007/s12031-022-02019-5
pmc: PMC9374629
doi:
Substances chimiques
DRD2 protein, human
0
Receptors, Dopamine D2
0
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1682-1694Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : MO 2363/3-2
Informations de copyright
© 2022. The Author(s).
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