Prescription-grade crystalline glucosamine sulfate as an add-on therapy to conventional treatments in erosive osteoarthritis of the hand: results from a 6-month observational retrospective study.
Erosive hand osteoarthritis
Hand osteoarthritis
Pain
Prescription-grade crystalline glucosamine sulfate
Retrospective study
Symptomatic slow-acting drugs for osteoarthritis
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
23
02
2022
accepted:
02
05
2022
pubmed:
1
6
2022
medline:
6
7
2022
entrez:
31
5
2022
Statut:
ppublish
Résumé
To evaluate the efficacy of prescription-grade Crystalline Glucosamine Sulfate (pCGS) as an add-on treatment to conventional therapy, compared to usual therapy alone, in patients with erosive osteoarthritis of the hand (EHOA). This 6-month retrospective case-control study included patients with concomitant knee osteoarthritis and symptomatic EHOA. Participants were stratified into two groups based on whether or not pCGS (1500 mg/day) was added to the conventional therapy (education and training in ergonomic principles, exercise and use on-demand of symptomatic drugs) for hand osteoarthritis. Patients were evaluated at baseline, after 3 and 6 months. Primary outcomes were the change from baseline to month 6 in Visual Analogue Scale (VAS) hand pain and in Functional Index for Hand Osteoarthritis (FIHOA) score. A set of secondary parameters was also evaluated. 123 patients were included as follows: 67 treated with pCGS in addition to conventional therapy (pCGS Group) and 56 with conventional therapy alone (Control Group). After 6 months a significant difference in VAS and in FIHOA score (p < 0.01 and p < 0.001, respectively) was observed in favor of pCGS Group. Similar results were found for morning stiffness duration (p < 0.05), health assessment questionnaire (p < 0.01) and physical and mental component score of 36-item short form (p < 0.05 and p < 0.001, respectively). A significant reduction of symptomatic drug consumption at 3 and 6 months was reported in the pCGS Group (p < 0.001). No serious adverse event was recorded in both groups. Despite all the limitations inherent to an observational study, our results suggest the potential effectiveness of pCGS, when used in combination with conventional therapy in EHOA. Further randomized placebo-controlled trials are needed to confirm these positive findings. ClinicalTrials.gov, http://www. gov , date of registration: February 2, 2022, NCT05237596. The present trial was retrospectively registered.
Identifiants
pubmed: 35637324
doi: 10.1007/s40520-022-02151-7
pii: 10.1007/s40520-022-02151-7
pmc: PMC9246990
doi:
Substances chimiques
Glucosamine
N08U5BOQ1K
Banques de données
ClinicalTrials.gov
['NCT05237596']
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1613-1625Informations de copyright
© 2022. The Author(s).
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