Association of Human Intestinal Microbiota with Lifestyle Activity, Adiposity, and Metabolic Profiles in Thai Children with Obesity.
Journal
Journal of nutrition and metabolism
ISSN: 2090-0724
Titre abrégé: J Nutr Metab
Pays: United States
ID NLM: 101526296
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
10
2021
revised:
23
03
2022
accepted:
19
04
2022
entrez:
31
5
2022
pubmed:
1
6
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Dysbiosis of intestinal microbiota may be linked to pathogenesis of obesity and metabolic disorders. This study compared the gut microbiome of obese Thai children with that of healthy controls and examined their relationships with host lifestyle, adiposity, and metabolic profiles. This cross-sectional study enrolled obese children aged 7-15. Body composition was evaluated using bioelectrical impedance analysis. Stool samples were analyzed by 16S rRNA sequencing using the Illumina MiSeq platform. Relative abundance and alpha- and beta-diversity were compared with normal-weight Thai children from a previous publication using Wilcoxon rank-sum test and ANOSIM. Relationships of gut microbiota with lifestyle activity, body composition, and metabolic profiles were assessed by canonical correlation analysis (CCA) and Spearman correlation. The study enrolled 164 obese children with a male percentage of 59%. Mean age was 10.4 ± 2.2 years with a BMI The composition and diversity of gut microbiota in obese Thai children were different from those of their normal-weight peers. Specific gut microbiota were associated with lifestyle, adiposity, and metabolic features in obese children. An interventional study is needed to support causality between specific gut microbiota and obesity.
Sections du résumé
Background
UNASSIGNED
Dysbiosis of intestinal microbiota may be linked to pathogenesis of obesity and metabolic disorders.
Objective
UNASSIGNED
This study compared the gut microbiome of obese Thai children with that of healthy controls and examined their relationships with host lifestyle, adiposity, and metabolic profiles.
Methods
UNASSIGNED
This cross-sectional study enrolled obese children aged 7-15. Body composition was evaluated using bioelectrical impedance analysis. Stool samples were analyzed by 16S rRNA sequencing using the Illumina MiSeq platform. Relative abundance and alpha- and beta-diversity were compared with normal-weight Thai children from a previous publication using Wilcoxon rank-sum test and ANOSIM. Relationships of gut microbiota with lifestyle activity, body composition, and metabolic profiles were assessed by canonical correlation analysis (CCA) and Spearman correlation.
Results
UNASSIGNED
The study enrolled 164 obese children with a male percentage of 59%. Mean age was 10.4 ± 2.2 years with a BMI
Conclusions
UNASSIGNED
The composition and diversity of gut microbiota in obese Thai children were different from those of their normal-weight peers. Specific gut microbiota were associated with lifestyle, adiposity, and metabolic features in obese children. An interventional study is needed to support causality between specific gut microbiota and obesity.
Identifiants
pubmed: 35637874
doi: 10.1155/2022/3029582
pmc: PMC9146442
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3029582Informations de copyright
Copyright © 2022 Chonnikant Visuthranukul et al.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest.
Références
Cell Mol Life Sci. 2016 Jan;73(1):147-62
pubmed: 26459447
Nature. 2006 Dec 21;444(7122):1027-31
pubmed: 17183312
Front Physiol. 2016 Feb 18;7:51
pubmed: 26924990
Nat Methods. 2016 Jul;13(7):581-3
pubmed: 27214047
Biomed Res Int. 2020 Aug 18;2020:6587136
pubmed: 32908903
J Pharm Biomed Anal. 2013 Jun;80:107-15
pubmed: 23542733
J Microbiol Biotechnol. 2017 Dec 28;27(12):2089-2093
pubmed: 29032640
PLoS One. 2013 Aug 27;8(8):e71108
pubmed: 24013136
Diabetes. 2016 Aug;65(8):2214-23
pubmed: 27217482
Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6
pubmed: 23193283
Eat Weight Disord. 2011 Dec;16(4):e242-9
pubmed: 22526130
Microb Ecol Health Dis. 2015 May 29;26:27663
pubmed: 26028277
BMC Microbiol. 2012 Nov 28;12:283
pubmed: 23190705
Environ Microbiol. 2013 Jan;15(1):211-26
pubmed: 22891823
Glob Pediatr Health. 2017 Oct 27;4:2333794X17736972
pubmed: 29119131
Nucleic Acids Res. 2013 Jan 7;41(1):e1
pubmed: 22933715
P R Health Sci J. 2015 Jun;34(2):60-4
pubmed: 26061054
Environ Microbiol. 2017 Jan;19(1):95-105
pubmed: 27450202
Diabetes. 2008 Jun;57(6):1470-81
pubmed: 18305141
Genes Nutr. 2017 Jun 15;12:18
pubmed: 28638490
Sci Rep. 2018 Jul 27;8(1):11356
pubmed: 30054529
Nutrients. 2018 Dec 19;10(12):
pubmed: 30572569
Biomed Res Int. 2017;2017:7585989
pubmed: 29214176
Microbes Environ. 2014;29(4):427-30
pubmed: 25283478
J Family Med Prim Care. 2015 Apr-Jun;4(2):187-92
pubmed: 25949965
Eur J Clin Nutr. 2000 Apr;54(4):288-97
pubmed: 10745279
Front Microbiol. 2018 Jun 22;9:1345
pubmed: 29988433
Br J Nutr. 2010 Feb;103(3):335-8
pubmed: 19849869
Gut Pathog. 2013 Apr 30;5(1):10
pubmed: 23631345
Microb Pathog. 2012 Aug;53(2):100-8
pubmed: 22634320
Korean J Fam Med. 2013 Mar;34(2):80-9
pubmed: 23560206
PeerJ. 2020 Jan 14;8:e8317
pubmed: 31976177
Microorganisms. 2020 Apr 15;8(4):
pubmed: 32326636
Nat Med. 2021 Feb;27(2):321-332
pubmed: 33432175
PLoS One. 2009 Sep 23;4(9):e7125
pubmed: 19774074
Genome Biol Evol. 2014 Mar;6(3):703-13
pubmed: 24625961
Genome Biol. 2011 Jun 24;12(6):R60
pubmed: 21702898
Obesity (Silver Spring). 2018 Feb;26(2):351-361
pubmed: 29280312
Eur J Clin Microbiol Infect Dis. 2015 Jul;34(7):1337-46
pubmed: 25761741
PLoS One. 2014 Jan 08;9(1):e84689
pubmed: 24416266
J Clin Biochem Nutr. 2016 Jul;59(1):65-70
pubmed: 27499582
Diabetes Care. 2004 Jun;27(6):1487-95
pubmed: 15161807
Int J Obes Relat Metab Disord. 2002 Jul;26(7):947-52
pubmed: 12080448
Genome Biol. 2012 Apr 16;13(9):R79
pubmed: 23013615
Obesity (Silver Spring). 2012 Nov;20(11):2257-61
pubmed: 22546742
Curr Mol Med. 2015;15(1):3-26
pubmed: 25601465
Nat Biotechnol. 2019 Aug;37(8):852-857
pubmed: 31341288
Nat Rev Endocrinol. 2015 Oct;11(10):577-91
pubmed: 26260141
Gut Microbes. 2011 Jan-Feb;2(1):25-33
pubmed: 21637015