An update of current therapeutic approach for Intervertebral Disc Degeneration: A review article.
Cell therapy
Current therapeutic approach
Gene therapy
Growth factors
Intervertebral disc degeneration
Stem cells
Journal
Annals of medicine and surgery (2012)
ISSN: 2049-0801
Titre abrégé: Ann Med Surg (Lond)
Pays: England
ID NLM: 101616869
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
25
02
2022
revised:
08
04
2022
accepted:
09
04
2022
entrez:
31
5
2022
pubmed:
1
6
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Intervertebral disc degeneration is a natural process of aging. It can cause physical, psychological, and socioeconomic impact due to the decreasing function of the spine and pain manifestation. Conservative and surgical treatment to correct symptoms and structural anomalies does not fully recover the degenerated disc. Several therapeutic approaches have been developed to improve the clinical result and patient's quality of life. This paper aims to review previous studies that discussed potential novel approach in order to make effective degenerated disc restoration. We tried to briefly describe IVD, IDD, also review several promising current therapeutic approaches for degenerated disc treatment, including its relevance to the degeneration process and limitation to be applied in a clinical setting. There are generally four current therapeutic approaches that we reviewed; growth factors, small molecules, gene therapy, and stem cells. These new approaches aim to not only correct the symptoms but also restore and delay the degeneration process.
Identifiants
pubmed: 35638079
doi: 10.1016/j.amsu.2022.103619
pii: S2049-0801(22)00379-X
pmc: PMC9142636
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
103619Informations de copyright
© 2022 The Authors.
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