A Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes.
Bicyclo[1.1.0]butane
Bicyclo[1.1.1]pentane
Bioisosteres
Fluorine
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
18 07 2022
18 07 2022
Historique:
received:
07
04
2022
pubmed:
1
6
2022
medline:
14
7
2022
entrez:
31
5
2022
Statut:
ppublish
Résumé
After more than 20 years of trials, a practical scalable approach to fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of the F-BCPs have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen in place of the fluorophenyl ring.
Identifiants
pubmed: 35638404
doi: 10.1002/anie.202205103
pmc: PMC9401599
doi:
Substances chimiques
Pentanes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202205103Informations de copyright
© 2022 The Authors. Published by Wiley-VCH GmbH.
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