Recent Hints on the Dual Role of Discs Large MAGUK Scaffold Protein 5 in Cancers and in Hepatocellular Carcinoma.
DLG5
EMT
HCC
cancer
liver cancer
polarity proteins
reviews
Journal
Frontiers in bioscience (Landmark edition)
ISSN: 2768-6698
Titre abrégé: Front Biosci (Landmark Ed)
Pays: Singapore
ID NLM: 101612996
Informations de publication
Date de publication:
20 05 2022
20 05 2022
Historique:
received:
20
01
2022
revised:
26
04
2022
accepted:
27
04
2022
entrez:
31
5
2022
pubmed:
1
6
2022
medline:
3
6
2022
Statut:
ppublish
Résumé
Discs large MAGUK scaffold protein 5 (DLG5) is a multi-domain member of membrane-associated guanylate kinase (MAGUK) family, which plays a major role in the maintenance of cell epithelial polarity being part of the SCRIB-LGL-DLG complex. Although polarity proteins have been generally considered tumor suppressors, recent discoveries led to reconsidering their role in cancer. This is also true for DLG5 in different cancer types, including hepatocellular carcinoma (HCC). In this cancer, DLG5 was negatively associated with malignant characteristics, however recent findings associated DLG5 expression with advanced stages of HCC.
Identifiants
pubmed: 35638431
pii: S2768-6701(22)00515-9
doi: 10.31083/j.fbl2705164
doi:
Substances chimiques
DLG5 protein, human
0
Membrane Proteins
0
Tumor Suppressor Proteins
0
Guanylate Kinases
EC 2.7.4.8
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
164Informations de copyright
© 2022 The Author(s). Published by IMR Press.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.