Invasion and Propagation of White Spot Syndrome Virus: Hijacking of the Cytoskeleton, Intracellular Transport Machinery, and Nuclear Import Transporters.
antiviral targeting
importin
intracellular trafficking
ivermectin
nuclear localization sequence
nuclear translocation
white spot syndrome virus
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
22 06 2022
22 06 2022
Historique:
pubmed:
1
6
2022
medline:
25
6
2022
entrez:
31
5
2022
Statut:
ppublish
Résumé
The pathogenesis of white spot syndrome virus (WSSV) is largely unclear. In this study, we found that actin nucleation and clathrin-mediated endocytosis were recruited for internalization of WSSV into crayfish hematopoietic tissue (Hpt) cells. This internalization was followed by intracellular transport of the invading virions via endocytic vesicles and endosomes. After envelope fusion within endosomes, the penetrated nucleocapsids were transported along microtubules toward the periphery of the nuclear pores. Furthermore, the nuclear transporter
Identifiants
pubmed: 35638850
doi: 10.1128/jvi.02205-21
pmc: PMC9215248
doi:
Substances chimiques
Antiviral Agents
0
Nuclear Pore Complex Proteins
0
Viral Structural Proteins
0
Ivermectin
70288-86-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0220521Références
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