Efficacy and Safety of MSC Cell Therapies for Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis.
COVID
MSC
cytokine storm
hospital recovery
pulmonary
Journal
Stem cells translational medicine
ISSN: 2157-6580
Titre abrégé: Stem Cells Transl Med
Pays: England
ID NLM: 101578022
Informations de publication
Date de publication:
20 07 2022
20 07 2022
Historique:
received:
29
09
2021
accepted:
09
03
2022
pubmed:
1
6
2022
medline:
23
7
2022
entrez:
31
5
2022
Statut:
ppublish
Résumé
MSC (a.k.a. mesenchymal stem cell or medicinal signaling cell) cell therapies show promise in decreasing mortality in acute respiratory distress syndrome (ARDS) and suggest benefits in treatment of COVID-19-related ARDS. We performed a meta-analysis of published trials assessing the efficacy and adverse events (AE) rates of MSC cell therapy in individuals hospitalized for COVID-19. Systematic searches were performed in multiple databases through November 3, 2021. Reports in all languages, including randomized clinical trials (RCTs), non-randomized interventional trials, and uncontrolled trials, were included. Random effects model was used to pool outcomes from RCTs and non-randomized interventional trials. Outcome measures included all-cause mortality, serious adverse events (SAEs), AEs, pulmonary function, laboratory, and imaging findings. A total of 736 patients were identified from 34 studies, which included 5 RCTs (n = 235), 7 non-randomized interventional trials (n = 370), and 22 uncontrolled comparative trials (n = 131). Patients aged on average 59.4 years and 32.2% were women. When compared with the control group, MSC cell therapy was associated with a reduction in all-cause mortality (RR = 0.54, 95% CI: 0.35-0.85, I 2 = 0.0%), reduction in SAEs (IRR = 0.36, 95% CI: 0.14-0.90, I 2 = 0.0%) and no significant difference in AE rate. A sub-group with pulmonary function studies suggested improvement in patients receiving MSC. These findings support the potential for MSC cell therapy to decrease all-cause mortality, reduce SAEs, and improve pulmonary function compared with conventional care. Large-scale double-blinded, well-powered RCTs should be conducted to further explore these results.
Identifiants
pubmed: 35640138
pii: 6594558
doi: 10.1093/stcltm/szac032
pmc: PMC9299515
doi:
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
688-703Informations de copyright
Published by Oxford University Press 2022.
Références
EBioMedicine. 2015 Mar 28;2(5):467-75
pubmed: 26137590
Infect Drug Resist. 2020 Sep 28;13:3295-3300
pubmed: 33061476
Circ Res. 2017 Oct 27;121(10):1192-1204
pubmed: 28974553
Lancet Respir Med. 2019 Feb;7(2):154-162
pubmed: 30455077
NPJ Regen Med. 2019 Dec 2;4:22
pubmed: 31815001
Eur J Med Res. 2021 Jun 8;26(1):51
pubmed: 34103090
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Crit Care. 2020 Dec 7;24(1):677
pubmed: 33287853
J Clin Invest. 2020 May 1;130(5):2620-2629
pubmed: 32217835
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
Clin Transl Med. 2021 Feb;11(2):e297
pubmed: 33634996
N Engl J Med. 2021 Feb 11;384(6):497-511
pubmed: 33264556
Int J Infect Dis. 2020 May;94:81-87
pubmed: 32205284
Signal Transduct Target Ther. 2020 Aug 27;5(1):172
pubmed: 32855385
Protein Cell. 2020 Oct;11(10):707-722
pubmed: 32519302
Signal Transduct Target Ther. 2021 Feb 10;6(1):58
pubmed: 33568628
Stem Cells Transl Med. 2021 May;10(5):660-673
pubmed: 33400390
JAMA. 2020 Apr 28;323(16):1574-1581
pubmed: 32250385
JAMA. 2020 Sep 3;:
pubmed: 32880615
J Intensive Care Med. 2021 Jun;36(6):681-688
pubmed: 33663244
Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15;305(10):L665-81
pubmed: 24039257
Clinics (Sao Paulo). 2021 May 17;76:e2604
pubmed: 34008772
JAMA. 2020 Apr 21;323(15):1499-1500
pubmed: 32159735
Int J Infect Dis. 2020 May;94:68-71
pubmed: 32179140
BMC Med Res Methodol. 2015 Nov 14;15:99
pubmed: 26573817
Stem Cells Transl Med. 2021 Sep;10(9):1279-1287
pubmed: 34102020
BMJ. 2021 Dec 3;375:n3013
pubmed: 34862184
Chest. 2021 Mar;159(3):1019-1040
pubmed: 33129791
PLoS One. 2013 Aug 30;8(8):e73659
pubmed: 24023689
Stem Cells Dev. 2021 Oct 1;30(19):947-969
pubmed: 34416823
Croat Med J. 2021 Jun 30;62(3):288-296
pubmed: 34212566
Bratisl Lek Listy. 2020;121(12):847-852
pubmed: 33300352
Cell Transplant. 2021 Jan-Dec;30:9636897211024942
pubmed: 34180719
Stem Cells Transl Med. 2020 Sep;9(9):1007-1022
pubmed: 32472653
Medicine (Baltimore). 2020 Jul 31;99(31):e21429
pubmed: 32756149
Stem Cell Res Ther. 2021 Jan 29;12(1):91
pubmed: 33514427
Curr Gene Ther. 2020;20(4):285-288
pubmed: 32867652
Lancet Respir Med. 2021 Dec;9(12):1407-1418
pubmed: 34480861
Stem Cells. 2010 Dec;28(12):2229-38
pubmed: 20945332
Intensive Care Med. 2020 May;46(5):846-848
pubmed: 32125452
Biotechnol Rep (Amst). 2020 May 14;26:e00467
pubmed: 32420049
Gut. 2011 Jun;60(6):788-98
pubmed: 21257987
Front Med. 2020 Oct;14(5):664-673
pubmed: 32761491
Stem Cell Res Ther. 2020 Jul 16;11(1):291
pubmed: 32678017
J Clin Med. 2019 Jul 12;8(7):
pubmed: 31336889
Stem Cell Rev Rep. 2021 Oct;17(5):1917-1925
pubmed: 34319510
Euro Surveill. 2021 Jul;26(27):
pubmed: 34240699
J Infect. 2020 Oct;81(4):647-679
pubmed: 32422152
Aging Dis. 2020 Mar 9;11(2):216-228
pubmed: 32257537
Nature. 2019 Feb;566(7742):39
pubmed: 30723355
J Cell Physiol. 2019 Apr;234(4):4970-4986
pubmed: 30216449
J Clin Invest. 2020 May 1;130(5):2202-2205
pubmed: 32217834
Med Clin (Engl Ed). 2020 Oct 9;155(7):318-319
pubmed: 32959021
J Infect Dev Ctries. 2020 Oct 31;14(10):1138-1145
pubmed: 33175709
Front Med (Lausanne). 2021 Jul 08;8:691329
pubmed: 34307417
J Musculoskelet Neuronal Interact. 2020 Mar 3;20(1):128-135
pubmed: 32131377
Ann Epidemiol. 2021 May;57:14-21
pubmed: 33662494
Stem Cells Int. 2014;2014:340257
pubmed: 25132856
Mayo Clin Proc. 2021 Apr;96(4):863-865
pubmed: 33715846
BMJ. 2019 Aug 28;366:l4898
pubmed: 31462531
BMJ Evid Based Med. 2018 Apr;23(2):60-63
pubmed: 29420178
Oncotarget. 2017 May 23;8(60):102600-102616
pubmed: 29254275
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Feb 10;41(2):145-151
pubmed: 32064853
J Turk Ger Gynecol Assoc. 2021 Mar 05;22(2):149-150
pubmed: 33663198
Cell Transplant. 2021 Jan-Dec;30:9636897211021008
pubmed: 34074163
Drug Des Devel Ther. 2019 Dec 19;13:4331-4340
pubmed: 31908418
Crit Care. 2020 Jul 11;24(1):420
pubmed: 32653043
Stem Cell Res Ther. 2020 Aug 18;11(1):361
pubmed: 32811531
Stem Cell Investig. 2020 Sep 08;7:17
pubmed: 33110915
Stat Med. 2004 May 15;23(9):1351-75
pubmed: 15116347
Cell Transplant. 2011;20(9):1395-408
pubmed: 21396175
Nat Med. 2012 Apr 15;18(5):759-65
pubmed: 22504485
World J Clin Cases. 2021 Mar 6;9(7):1705-1713
pubmed: 33728315
Aging Dis. 2021 Apr 1;12(2):360-370
pubmed: 33815870
J Cell Mol Med. 2021 Nov;25(22):10554-10564
pubmed: 34632708
Stem Cell Res Ther. 2020 May 27;11(1):207
pubmed: 32460839
Stem Cells Transl Med. 2018 Dec;7(12):857-866
pubmed: 30255989
Am J Respir Crit Care Med. 2020 Sep 15;202(6):812-821
pubmed: 32584597
Basic Res Cardiol. 2020 May 12;115(4):36
pubmed: 32399655
Cytokine. 2020 Sep;133:155151
pubmed: 32544563
Stem Cell Res Ther. 2021 Jul 16;12(1):410
pubmed: 34271988
Regen Med. 2010 Jan;5(1):121-43
pubmed: 20017699
Nat Med. 2020 Oct;26(10):1636-1643
pubmed: 32839624
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
Expert Opin Biol Ther. 2015 Apr;15(4):477-9
pubmed: 25539087
Anaesth Crit Care Pain Med. 2020 Aug;39(4):487-489
pubmed: 32654909
JAMA. 2021 Aug 10;326(6):499-518
pubmed: 34228774
EClinicalMedicine. 2020 Aug;25:100454
pubmed: 32838232
Cell Prolif. 2020 Dec;53(12):e12947
pubmed: 33205469
Mayo Clin Proc. 2020 Feb;95(2):406-414
pubmed: 31785831