Incidence of HPVs, EBV, and MMTV-Like Virus in Breast Cancer in Qatar.
Breast cancer
Epstein-Barr virus
Human papillomavirus
Mouse mammary tumor virus-like virus
Qatari population
Journal
Intervirology
ISSN: 1423-0100
Titre abrégé: Intervirology
Pays: Switzerland
ID NLM: 0364265
Informations de publication
Date de publication:
2022
2022
Historique:
received:
25
11
2021
accepted:
15
04
2022
pubmed:
1
6
2022
medline:
26
10
2022
entrez:
31
5
2022
Statut:
ppublish
Résumé
Human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and mouse mammary tumor virus-like virus (MMTV-like virus) can be present and contribute to breast cancer development and progression. However, the role of these oncoviruses and their crosstalk in breast cancer is still unclear. We explored the co-presence of high-risk HPVs, EBV, and MMTV-like virus in 74 breast cancer samples from Qatar using PCR. We found the presence of HPV and EBV in 65% and 49% of our cancer sample cohorts; 47% of the samples are positive for both oncoviruses. The MMTV-like virus alone was detected in 15% of the samples with no significant association with clinicopathological features. The three oncoviruses were co-present in 14% of the cases; no significant association was noted between the co-presence of these viruses and the clinicopathological features. Despite the presence of the oncoviruses, additional studies are necessary to understand their interactions in human breast carcinogenesis.
Identifiants
pubmed: 35640537
pii: 000525277
doi: 10.1159/000525277
pmc: PMC9677861
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
188-194Informations de copyright
© 2022 The Author(s). Published by S. Karger AG, Basel.
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