Involvement of spinal G-protein inwardly rectifying potassium (GIRK) channels in the enhanced antinociceptive effects of the activation of both μ-opioid and cannabinoid CB

Animals G Protein-Coupled Inwardly-Rectifying Potassium Channels / metabolism Mice Morphine / pharmacology Neuralgia / drug therapy Receptors, Cannabinoid / metabolism Receptors, Opioid, mu / metabolism
Antinociceptive effect Cannabinoid G protein-coupled inwardly-rectifying potassium channels Spinal cord μ-Opioid

Journal

Journal of pharmacological sciences
ISSN: 1347-8648
Titre abrégé: J Pharmacol Sci
Pays: Japan
ID NLM: 101167001

Informations de publication

Date de publication:
Jul 2022
Historique:
received: 30 01 2022
revised: 30 03 2022
accepted: 08 04 2022
entrez: 31 5 2022
pubmed: 1 6 2022
medline: 3 6 2022
Statut: ppublish

Résumé

Neuropathic pain is refractory to opioid analgesics. Since there are functional linkages between μ-opioid receptors (MOR) and cannabinoid receptors (CBR), the present study was designed to investigate the interactions between MOR and CB

Identifiants

DOI: 10.1016/j.jphs.2022.04.002 PMID: 35641032
pubmed: 35641032
pii: S1347-8613(22)00028-7
doi: 10.1016/j.jphs.2022.04.002
pii:
doi:

Substances chimiques

G Protein-Coupled Inwardly-Rectifying Potassium Channels 0
Receptors, Cannabinoid 0
Receptors, Opioid, mu 0
Morphine 76I7G6D29C

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

85-92

Informations de copyright

Copyright © 2022 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest None of the authors have any conflict of interest to disclose related to this submission.

Auteurs

Yoshinori Takemura (Y)

Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo, Japan; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo, Japan; Department of Anesthesiology, Toyama University Hospital, Toyama-shi, Toyama, Japan.

Yuka Sudo (Y)

Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda-shi, Chiba, Japan; Division of Cancer Pathophysiology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.

Tomoya Saeki (T)

Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo, Japan.

Shinji Kurata (S)

Department of Anesthesiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki-shi, Nagasaki, Japan.

Tsutomu Suzuki (T)

Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo, Japan.

Tomohisa Mori (T)

Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo, Japan; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo, Japan. Electronic address: t-mori@hoshi.ac.jp.

Yasuhito Uezono (Y)

Division of Cancer Pathophysiology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Department of Pain Control Research, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan. Electronic address: yuezono@jikei.ac.jp.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Involvement of spinal G-protein inwardly...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques rectifiants entrants › Canaux potassiques rectifiants entrants couplés aux protéines G › Involvement of spinal G-protein inwardly...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Involvement of spinal G-protein inwardly...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Phénanthrènes › Morphinanes › Dérivés de la morphine › Morphine › Involvement of spinal G-protein inwardly...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Névralgie › Involvement of spinal G-protein inwardly...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs de cannabinoïdes › Involvement of spinal G-protein inwardly...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs aux opioïdes › Récepteur mu › Involvement of spinal G-protein inwardly...