Autophagy modulation in multiple sclerosis and experimental autoimmune encephalomyelitis.
autophagy
experimental autoimmune encephalomyelitis
immune cells
inflammatory factors
multiple sclerosis
Journal
Clinical and experimental immunology
ISSN: 1365-2249
Titre abrégé: Clin Exp Immunol
Pays: England
ID NLM: 0057202
Informations de publication
Date de publication:
19 08 2022
19 08 2022
Historique:
received:
11
10
2021
revised:
01
02
2022
accepted:
14
02
2022
pubmed:
1
6
2022
medline:
24
8
2022
entrez:
31
5
2022
Statut:
ppublish
Résumé
Multiple sclerosis (MS), a white matter demyelinating disease of the central nervous system (CNS), is characterized by neuroinflammatory and neurodegenerative. Experimental autoimmune encephalomyelitis (EAE) is a commonly used animal model for investigating pathogenic mechanisms of MS, representing the destruction of the blood-brain barrier (BBB), the activation of T cells, and the infiltration of myeloid cells. An increasing number of studies have documented that autophagy plays a critical role in the pathogenesis of both MS and EAE. Autophagy maintains CNS homeostasis by degrading the damaged organelles and abnormal proteins. Furthermore, autophagy is involved in inflammatory responses by regulating the activation of immune cells and the secretion of inflammatory factors. However, the specific mechanisms of autophagy involved in MS and EAE are not completely understood. In this review, we will summarize the complex mechanisms of autophagy in MS and EAE, providing potential therapeutic approaches for the management of MS.
Identifiants
pubmed: 35641229
pii: 6529269
doi: 10.1093/cei/uxac017
pmc: PMC9390842
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
140-150Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Immunology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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