State or trait: the neurobiology of anorexia nervosa - contributions of a functional magnetic resonance imaging study.
Anorexia nervosa
Functional magnetic resonance imaging
Recovery
State
Trait
Journal
Journal of eating disorders
ISSN: 2050-2974
Titre abrégé: J Eat Disord
Pays: England
ID NLM: 101610672
Informations de publication
Date de publication:
31 May 2022
31 May 2022
Historique:
received:
19
03
2022
accepted:
23
05
2022
entrez:
1
6
2022
pubmed:
2
6
2022
medline:
2
6
2022
Statut:
epublish
Résumé
The understanding of the cerebral neurobiology of anorexia nervosa (AN) with respect to state- versus trait-related abnormalities is limited. There is evidence of restitution of structural brain alterations with clinical remission. However, with regard to functional brain abnormalities, this issue has not yet been clarified. We compared women with AN (n = 31), well-recovered female participants (REC) (n = 18) and non-patients (NP) (n = 27) cross-sectionally. Functional magnetic resonance imaging was performed to compare neural responses to food versus non-food images. Additionally, affective ratings were assessed. Functional responses and affective ratings did not differ between REC and NP, even when applying lenient thresholds for the comparison of neural responses. Comparing REC and AN, the latter showed lower valence and higher arousal ratings for food stimuli, and neural responses differed with lenient thresholds in an occipital region. The data are in line with some previous findings and suggest restitution of cerebral function with clinical recovery. Furthermore, affective ratings did not differ from NP. These results need to be verified in intra-individual longitudinal studies. There is abundant evidence of structural and functional brain alterations during the acute stage of anorexia nervosa (AN), although affected brain areas differ based on various study methodologies. Meanwhile, investigations indicate that brain structure normalizes with weight and clinical restitution. The current cross-sectional investigation examines acutely ill AN patients, healthy controls, i.e. non-patients (NP) and well-recovered individuals (REC), with respect to brain function. Functional cerebral responses of participants exposed to food pictures were investigated. Neither in terms of function nor emotional experience of food stimuli, the REC differed from the NP group. This study points to brain function normalizing with clinical and weight restoration, which should be verified in intra-individual longitudinal studies.
Sections du résumé
BACKGROUND
BACKGROUND
The understanding of the cerebral neurobiology of anorexia nervosa (AN) with respect to state- versus trait-related abnormalities is limited. There is evidence of restitution of structural brain alterations with clinical remission. However, with regard to functional brain abnormalities, this issue has not yet been clarified.
METHODS
METHODS
We compared women with AN (n = 31), well-recovered female participants (REC) (n = 18) and non-patients (NP) (n = 27) cross-sectionally. Functional magnetic resonance imaging was performed to compare neural responses to food versus non-food images. Additionally, affective ratings were assessed.
RESULTS
RESULTS
Functional responses and affective ratings did not differ between REC and NP, even when applying lenient thresholds for the comparison of neural responses. Comparing REC and AN, the latter showed lower valence and higher arousal ratings for food stimuli, and neural responses differed with lenient thresholds in an occipital region.
CONCLUSIONS
CONCLUSIONS
The data are in line with some previous findings and suggest restitution of cerebral function with clinical recovery. Furthermore, affective ratings did not differ from NP. These results need to be verified in intra-individual longitudinal studies.
There is abundant evidence of structural and functional brain alterations during the acute stage of anorexia nervosa (AN), although affected brain areas differ based on various study methodologies. Meanwhile, investigations indicate that brain structure normalizes with weight and clinical restitution. The current cross-sectional investigation examines acutely ill AN patients, healthy controls, i.e. non-patients (NP) and well-recovered individuals (REC), with respect to brain function. Functional cerebral responses of participants exposed to food pictures were investigated. Neither in terms of function nor emotional experience of food stimuli, the REC differed from the NP group. This study points to brain function normalizing with clinical and weight restoration, which should be verified in intra-individual longitudinal studies.
Autres résumés
Type: plain-language-summary
(eng)
There is abundant evidence of structural and functional brain alterations during the acute stage of anorexia nervosa (AN), although affected brain areas differ based on various study methodologies. Meanwhile, investigations indicate that brain structure normalizes with weight and clinical restitution. The current cross-sectional investigation examines acutely ill AN patients, healthy controls, i.e. non-patients (NP) and well-recovered individuals (REC), with respect to brain function. Functional cerebral responses of participants exposed to food pictures were investigated. Neither in terms of function nor emotional experience of food stimuli, the REC differed from the NP group. This study points to brain function normalizing with clinical and weight restoration, which should be verified in intra-individual longitudinal studies.
Identifiants
pubmed: 35641995
doi: 10.1186/s40337-022-00598-7
pii: 10.1186/s40337-022-00598-7
pmc: PMC9158182
doi:
Types de publication
Journal Article
Langues
eng
Pagination
77Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : JO 744/2-1
Informations de copyright
© 2022. The Author(s).
Références
Front Psychiatry. 2019 Jul 08;10:490
pubmed: 31338044
Psychiatry Res Neuroimaging. 2019 Jun 30;288:76-84
pubmed: 30149963
Psychoneuroendocrinology. 2022 Jan;135:105576
pubmed: 34781223
Eat Weight Disord. 2021 Mar;26(2):667-677
pubmed: 32350776
Psychiatry Res Neuroimaging. 2016 Dec 30;258:44-53
pubmed: 27866012
Int J Eat Disord. 2020 Aug;53(8):1204-1208
pubmed: 31469436
Psychiatry Res. 2011 Mar 31;191(3):189-95
pubmed: 21316204
Am J Psychiatry. 2003 Apr;160(4):636-45
pubmed: 12668349
Neuroimage Clin. 2016 Nov 02;12:1045-1047
pubmed: 27995071
J Neural Transm (Vienna). 2016 Aug;123(8):949-59
pubmed: 27188331
Am J Psychiatry. 2020 Jul 1;177(7):601-610
pubmed: 32160766
Int J Eat Disord. 2018 Mar;51(3):250-261
pubmed: 29405338
Hum Brain Mapp. 2021 Oct 15;42(15):5154-5169
pubmed: 34296492
Int J Eat Disord. 2020 Aug;53(8):1270-1279
pubmed: 31840847
Psychiatry Res. 2013 Nov 30;214(2):132-41
pubmed: 23993362
Biol Psychiatry. 2011 Oct 15;70(8):736-743
pubmed: 21714958
Am J Psychiatry. 2013 Oct;170(10):1143-51
pubmed: 23732817
Neuropsychologia. 2010 Dec;48(14):4111-6
pubmed: 20933530
Front Psychiatry. 2020 Aug 05;11:777
pubmed: 32848943
J Eat Disord. 2017 Feb 27;5:5
pubmed: 28261479
Hum Brain Mapp. 2019 May;40(7):2017-2032
pubmed: 30318709
Biol Psychiatry. 2018 Feb 1;83(3):224-234
pubmed: 28967386
Magn Reson Med. 2004 Nov;52(5):1156-66
pubmed: 15508146
Transl Psychiatry. 2021 Oct 16;11(1):532
pubmed: 34657121
Eur Eat Disord Rev. 2019 May;27(3):315-322
pubmed: 30666763
J Eat Disord. 2019 Jun 20;7:22
pubmed: 31249687
Behav Res Ther. 2010 Mar;48(3):194-202
pubmed: 19945094
J Clin Med. 2020 Mar 25;9(4):
pubmed: 32218141
Neuropsychologia. 2019 Aug;131:1-8
pubmed: 31145908
Int J Eat Disord. 2018 Sep;51(9):1056-1069
pubmed: 30212599
Curr Neuropharmacol. 2018;16(8):1164-1173
pubmed: 29119931
Ann N Y Acad Sci. 2010 Mar;1191:133-55
pubmed: 20392279
Int J Eat Disord. 2016 Jun;49(6):603-12
pubmed: 27083785
Cogn Neuropsychiatry. 2013;18(1-2):83-114
pubmed: 22994309
Biol Psychiatry. 2003 Nov 1;54(9):934-42
pubmed: 14573322
J Psychiatry Neurosci. 2012 Sep;37(5):322-32
pubmed: 22498079
J Psychiatry Neurosci. 2019 Oct 09;45(2):108-116
pubmed: 31595737
Am J Psychiatry. 2004 Jul;161(7):1238-46
pubmed: 15229057
J Am Acad Child Adolesc Psychiatry. 2012 Aug;51(8):832-841.e11
pubmed: 22840554
Eur Eat Disord Rev. 2017 Mar;25(2):114-122
pubmed: 28217879
Clin Psychol Rev. 2020 Nov;81:101905
pubmed: 32891022
Lancet Psychiatry. 2015 Dec;2(12):1099-111
pubmed: 26514083
Front Behav Neurosci. 2015 Feb 27;9:46
pubmed: 25774128
J Clin Med. 2019 Jul 18;8(7):
pubmed: 31323803
PLoS Biol. 2016 Jul 07;14(7):e1002506
pubmed: 27389358
Am J Psychiatry. 2017 Jun 1;174(6):557-565
pubmed: 28231717
J Eat Disord. 2017 Dec 1;5:38
pubmed: 29214022
Int J Eat Disord. 2006 Apr;39(3):175-83
pubmed: 16485268
Psychother Psychosom. 2019;88(4):238-240
pubmed: 30557882
J Eat Disord. 2013 Apr 15;1:13
pubmed: 24999394
Psychol Sci. 2020 Jul;31(7):792-806
pubmed: 32489141
Biopsychosoc Med. 2018 Oct 31;12:15
pubmed: 30450124
Curr Neuropharmacol. 2018;16(8):1150-1163
pubmed: 29046154
World J Biol Psychiatry. 2014 May;15(4):307-16
pubmed: 22540408
Neuroimage. 2020 Feb 1;206:116189
pubmed: 31521825
Psychol Med. 2019 Jul;49(9):1555-1564
pubmed: 30149815
Biol Psychiatry. 2015 Nov 1;78(9):606-14
pubmed: 25641636
J Clin Med. 2020 Apr 30;9(5):
pubmed: 32365843
Neuropsychopharmacology. 2008 Feb;33(3):513-23
pubmed: 17487228
J Eat Disord. 2017 Jun 14;5:20
pubmed: 28630708
Am J Psychiatry. 2002 Aug;159(8):1284-93
pubmed: 12153817
Neuroimage. 2014 May 1;91:412-9
pubmed: 24412399