Age-dependent changes in Wnt signaling components and synapse number are differentially affected between brain regions.
Aging
LRP6
Synaptic loss
Wnt signaling
Journal
Experimental gerontology
ISSN: 1873-6815
Titre abrégé: Exp Gerontol
Pays: England
ID NLM: 0047061
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
02
03
2022
accepted:
23
05
2022
pubmed:
2
6
2022
medline:
1
7
2022
entrez:
1
6
2022
Statut:
ppublish
Résumé
Wnt signaling plays an important role in adult brain function, and its dysregulation has been implicated in functional decline during aging as well as in some neurodegenerative diseases, such as Alzheimer's disease. In the adult brain, the Wnt pathway contributes to synapse formation and maintenance, axonal remodeling, and dendrite outgrowth. Recent findings indicate a downregulation of Wnt signaling in the aged brain in different models, but it has not been associated with changes in the number and structure of central synapses. The expression and distribution of Wnt components in different brain regions may vary with age, which may have important implications for brain homeostasis manifesting as different behavioral alterations. Thus, in the present work, we analyzed the expression levels and protein content of different molecules of the Wnt pathway in young and aged rats in the cerebral cortex, hippocampus and cerebellum and discussed their correlation with changes in synaptic number and morphology.
Identifiants
pubmed: 35642846
pii: S0531-5565(22)00162-0
doi: 10.1016/j.exger.2022.111854
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111854Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.