Exercise protects intestinal epithelial barrier from high fat diet- induced permeabilization through SESN2/AMPKα1/HIF-1α signaling.
Sestrin2
antibiotics
exercise
gut barrier integrity
gut microbiota
obesity
Journal
The Journal of nutritional biochemistry
ISSN: 1873-4847
Titre abrégé: J Nutr Biochem
Pays: United States
ID NLM: 9010081
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
12
10
2021
revised:
19
02
2022
accepted:
14
04
2022
pubmed:
2
6
2022
medline:
2
8
2022
entrez:
1
6
2022
Statut:
ppublish
Résumé
Over-nutrition and a sedentary lifestyle are associated with increased intestinal permeability. This condition promotes obesity and associated metabolic disorders. Sestrin2 (SESN2) is a stress-inducible protein thought to promote the survival and recovery of epithelial cells and act as a positive regulator in exercise-induced improvements of glycolipid metabolism. Here we aimed to test the hypothesis that chronic exercise can protect intestinal barrier function against high-fat diet induced permeabilization through SESN2. WT and SESN2
Identifiants
pubmed: 35643285
pii: S0955-2863(22)00130-9
doi: 10.1016/j.jnutbio.2022.109059
pii:
doi:
Types de publication
Journal Article
Randomized Controlled Trial, Veterinary
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109059Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.