Opisthorchis viverrini infection induces metabolic disturbances in hamsters fed with high fat/high fructose diets: Implications for liver and kidney pathologies.
Gut microbiota
High-fat
High-fructose diets
Kidney damage
Liver fluke
Non–alcoholic fatty liver disease
Nuclear magnetic resonance spectroscopy
Journal
The Journal of nutritional biochemistry
ISSN: 1873-4847
Titre abrégé: J Nutr Biochem
Pays: United States
ID NLM: 9010081
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
13
04
2021
revised:
15
02
2022
accepted:
19
04
2022
pubmed:
2
6
2022
medline:
2
8
2022
entrez:
1
6
2022
Statut:
ppublish
Résumé
A combination of Opisthorchis viverrini infection and high fat/high fructose diets (HFa/HFr) intake is likely to enhance fatty liver and kidney pathologies. Here we investigated the combined effects of chronic O. viverrini infection and HFa/HFr intake on liver and kidney pathologies, metabolism, and gut microbiome in hamsters. Animals were infected with O. viverrini and fed with either standard chow (OV group) or HFa/HFr diet (OH group) and non-infected hamsters were fed with either standard chow (NC) or HFa/HFr diet (HF) for 8 months. The OH group exhibited dyslipidemia and the highest severity of fatty liver. Tubular damage, inflammatory cell infiltration, and tubular fibrosis were the most prominently observed in this group, supported by increased expression of KIM-1, HMGB-1, and MCP-1. Urinary
Identifiants
pubmed: 35643287
pii: S0955-2863(22)00124-3
doi: 10.1016/j.jnutbio.2022.109053
pii:
doi:
Substances chimiques
Fructose
30237-26-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109053Subventions
Organisme : Medical Research Council
ID : MR/P002536/1
Pays : United Kingdom
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.