Lineage tracing analysis defines erythropoietin-producing cells as a distinct subpopulation of resident fibroblasts with unique behaviors.

Animals Erythropoietin / genetics Fibroblasts / pathology Fibrosis Kidney / pathology Mice Ureteral Obstruction / pathology
erythropoietin kidney fibrosis renal Epo-producing cells (REP cells) renal anemia

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
08 2022
Historique:
received: 09 05 2021
revised: 16 04 2022
accepted: 27 04 2022
pubmed: 2 6 2022
medline: 27 7 2022
entrez: 1 6 2022
Statut: ppublish

Résumé

Erythropoietin (Epo) is produced by a subpopulation of resident fibroblasts in the healthy kidney. We have previously demonstrated that, during kidney fibrosis, kidney fibroblasts including Epo-producing cells transdifferentiate into myofibroblasts and lose their Epo-producing ability. However, it remains unclear whether Epo-producing cells survive and transform into myofibroblasts during fibrosis because previous studies did not specifically label Epo-producing cells in pathophysiological conditions. Here, we generated Epo

Identifiants

DOI: 10.1016/j.kint.2022.04.026 PMID: 35644281
pubmed: 35644281
pii: S0085-2538(22)00376-3
doi: 10.1016/j.kint.2022.04.026
pii:
doi:

Substances chimiques

Erythropoietin 11096-26-7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

280-292

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Auteurs

Keiichi Kaneko (K)

Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Yuki Sato (Y)

Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Medical Innovation Center, TMK Project, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Eiichiro Uchino (E)

Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Biomedical Data Intelligence, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Naoya Toriu (N)

Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Mayo Shigeta (M)

Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.

Hiroshi Kiyonari (H)

Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.

Shuichiro Endo (S)

Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Shingo Fukuma (S)

Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Motoko Yanagita (M)

Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan. Electronic address: motoy@kuhp.kyoto-u.ac.jp.

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Classifications MeSH

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