Uptake-leak balance of SR Ca

Animals Arrhythmias, Cardiac / metabolism Calcium / metabolism Calcium Signaling Isoproterenol / pharmacology Mice Myocytes, Cardiac / metabolism Ryanodine Receptor Calcium Release Channel / metabolism Sarcoplasmic Reticulum / metabolism
Arrhythmia Calcium signaling Catecholaminergic polymorphic ventricular tachycardia Channelopathy Ryanodine receptor Sarcoplasmic reticulum calcium pump

Journal

Journal of molecular and cellular cardiology
ISSN: 1095-8584
Titre abrégé: J Mol Cell Cardiol
Pays: England
ID NLM: 0262322

Informations de publication

Date de publication:
09 2022
Historique:
received: 24 08 2021
revised: 01 04 2022
accepted: 22 05 2022
pubmed: 2 6 2022
medline: 24 8 2022
entrez: 1 6 2022
Statut: ppublish

Résumé

Mutations of the RyR2 are channelopathies that can predispose to life threatening catecholaminergic polymorphic ventricular tachycardias (CPVTs) during exercise or stress. However, the cellular and molecular mechanisms that are causal for the arrhythmias downstream of the β-adrenergic receptor (β-AR) activation are not defined. They may be specific and different for each particular RyR2 mutation. Obvious possibilities are the phosphorylation of the mutated RyR2s or the stimulation of the SR Ca

Identifiants

DOI: 10.1016/j.yjmcc.2022.05.011 PMID: 35644481
pubmed: 35644481
pii: S0022-2828(22)00104-3
doi: 10.1016/j.yjmcc.2022.05.011
pii:
doi:

Substances chimiques

Ryanodine Receptor Calcium Release Channel 0
Isoproterenol L628TT009W
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-14

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Ruben Lopez (R)

Department of Physiology, University of Bern, Bern, Switzerland.

Radoslav Janicek (R)

Department of Physiology, University of Bern, Bern, Switzerland.

Miguel Fernandez-Tenorio (M)

Department of Physiology, University of Bern, Bern, Switzerland.

Marianne Courtehoux (M)

Department of Physiology, University of Bern, Bern, Switzerland.

Lluis Matas (L)

Department of Physiology, University of Bern, Bern, Switzerland.

Pascale Gerbaud (P)

INSERM UMR-S 1180, Université Paris Saclay, Châtenay-Malabry, France.

Ana M Gomez (AM)

INSERM UMR-S 1180, Université Paris Saclay, Châtenay-Malabry, France.

Marcel Egger (M)

Department of Physiology, University of Bern, Bern, Switzerland.

Ernst Niggli (E)

Department of Physiology, University of Bern, Bern, Switzerland. Electronic address: ernst.niggli@unibe.ch.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Uptake-leak balance of SR Ca
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Uptake-leak balance of SR Ca
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Uptake-leak balance of SR Ca
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › Uptake-leak balance of SR Ca
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Isoprénaline › Uptake-leak balance of SR Ca
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Uptake-leak balance of SR Ca
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Uptake-leak balance of SR Ca
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canal de libération du calcium du récepteur à la ryanodine › Uptake-leak balance of SR Ca
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Réticulum endoplasmique › Réticulum endoplasmique lisse › Réticulum sarcoplasmique › Uptake-leak balance of SR Ca