Crosstalk between CYP2E1 and PPAR
CYP2E1
FGF21
Metabolic enzyme
Nuclear receptor
Obesity
PPARα
Journal
Acta pharmaceutica Sinica. B
ISSN: 2211-3835
Titre abrégé: Acta Pharm Sin B
Pays: Netherlands
ID NLM: 101600560
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
18
11
2021
revised:
11
01
2022
accepted:
28
01
2022
entrez:
1
6
2022
pubmed:
2
6
2022
medline:
2
6
2022
Statut:
ppublish
Résumé
Although the functions of metabolic enzymes and nuclear receptors in controlling physiological homeostasis have been established, their crosstalk in modulating metabolic disease has not been explored. Genetic ablation of the xenobiotic-metabolizing cytochrome P450 enzyme CYP2E1 in mice markedly induced adipose browning and increased energy expenditure to improve obesity. CYP2E1 deficiency activated the expression of hepatic peroxisome proliferator-activated receptor alpha (PPAR
Identifiants
pubmed: 35646522
doi: 10.1016/j.apsb.2022.02.004
pii: S2211-3835(22)00054-5
pmc: PMC9136617
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2224-2238Informations de copyright
© 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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