Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4
CXCR4 receptor
Cancer therapy
Cell targeting
HNSCC
Nanotoxins
Protein nanoparticles
Recombinant proteins
Targeted drug delivery
Journal
Acta pharmaceutica Sinica. B
ISSN: 2211-3835
Titre abrégé: Acta Pharm Sin B
Pays: Netherlands
ID NLM: 101600560
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
05
07
2021
revised:
03
09
2021
accepted:
15
09
2021
entrez:
1
6
2022
pubmed:
2
6
2022
medline:
2
6
2022
Statut:
ppublish
Résumé
Loco-regional recurrences and distant metastases represent the main cause of head and neck squamous cell carcinoma (HNSCC) mortality. The overexpression of chemokine receptor 4 (CXCR4) in HNSCC primary tumors associates with higher risk of developing loco-regional recurrences and distant metastases, thus making CXCR4 an ideal entry pathway for targeted drug delivery. In this context, our group has generated the self-assembling protein nanocarrier T22-GFP-H6, displaying multiple T22 peptidic ligands that specifically target CXCR4. This study aimed to validate T22-GFP-H6 as a suitable nanocarrier to selectively deliver cytotoxic agents to CXCR4
Identifiants
pubmed: 35646535
doi: 10.1016/j.apsb.2021.09.030
pii: S2211-3835(21)00391-9
pmc: PMC9136533
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2578-2591Informations de copyright
© 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
Références
Nat Nanotechnol. 2013 Feb;8(2):137-43
pubmed: 23334168
Adv Ther. 2018 Feb;35(2):161-172
pubmed: 29396680
Clin Cancer Res. 2011 Dec 1;17(23):7248-64
pubmed: 21868764
Theranostics. 2020 Apr 6;10(12):5169-5180
pubmed: 32373205
Urol Oncol. 2008 Jan-Feb;26(1):57-64
pubmed: 18190833
Cell Stem Cell. 2007 Sep 13;1(3):241-2
pubmed: 18371356
Nat Biotechnol. 2006 Oct;24(10):1211-7
pubmed: 17033654
J Control Release. 2013 Mar 10;166(2):182-94
pubmed: 23262199
Acta Biomater. 2019 Jan 1;83:257-264
pubmed: 30366134
Biomolecules. 2020 Feb 26;10(3):
pubmed: 32111076
Biomaterials. 2020 May;240:119902
pubmed: 32105817
Oncotarget. 2017 Nov 20;8(68):112739-112747
pubmed: 29348861
Head Neck. 2013 Dec;35(12):1819-28
pubmed: 23468253
Trends Biotechnol. 2018 Mar;36(3):318-335
pubmed: 29246477
Head Neck. 2000 Oct;22(7):680-6
pubmed: 11002323
J Control Release. 2011 Aug 10;153(3):198-205
pubmed: 21663778
Med Sci (Basel). 2016 Mar 08;4(1):
pubmed: 29083369
Biomaterials. 2012 Nov;33(33):8714-22
pubmed: 22954515
J Clin Immunol. 2016 May;36 Suppl 1:100-7
pubmed: 27003914
J Mater Chem B. 2017 Jun 21;5(23):4393-4405
pubmed: 32263966
Oncol Rep. 2013 Jun;29(6):2325-31
pubmed: 23563306
Nat Rev Cancer. 2017 Jan;17(1):20-37
pubmed: 27834398
Eur J Pharm Biopharm. 2015 Jun;93:52-79
pubmed: 25813885
J Control Release. 2010 Dec 1;148(2):135-46
pubmed: 20797419
Acta Pharmacol Sin. 2013 Jun;34(6):732-40
pubmed: 23685952
J Hematol Oncol. 2020 Apr 15;13(1):36
pubmed: 32295630
Nat Commun. 2020 Sep 24;11(1):4836
pubmed: 32973157
Eur Arch Otorhinolaryngol. 2016 Dec;273(12):4525-4533
pubmed: 27328961
Eur J Cancer. 2013 Jan;49(1):219-30
pubmed: 22683307
ACS Nano. 2014 May 27;8(5):4166-76
pubmed: 24708510
Nat Rev Drug Discov. 2010 Aug;9(8):615-27
pubmed: 20616808
Cancer Res. 2007 Apr 1;67(7):3153-61
pubmed: 17409422
J Virol. 1999 Sep;73(9):7489-96
pubmed: 10438838
J Natl Cancer Inst. 2015 Dec 09;107(12):djv344
pubmed: 26656751
Cell Cycle. 2008 Jan 15;7(2):188-93
pubmed: 18256530
EMBO Mol Med. 2018 Oct;10(10):
pubmed: 30190334
Int J Pharm. 2018 Dec 1;552(1-2):328-339
pubmed: 30308270
Chembiochem. 2019 Nov 4;20(21):2729-2737
pubmed: 30973187
J Clin Oncol. 2015 Oct 10;33(29):3305-13
pubmed: 26351341
Head Neck. 2010 Apr;32(4):417-26
pubmed: 19760794
Oncogene. 2016 Feb 18;35(7):816-26
pubmed: 25961926
Invest New Drugs. 2018 Feb;36(1):121-135
pubmed: 29027591
Int J Nanomedicine. 2012;7:4533-44
pubmed: 22923991
Haematologica. 2020 Mar;105(3):741-753
pubmed: 31248974
J Clin Invest. 2012 Jun;122(6):1951-7
pubmed: 22833868
J Control Release. 2018 Mar 28;274:81-92
pubmed: 29408658
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
ACS Nano. 2017 Dec 26;11(12):11773-11776
pubmed: 29206030
Nat Biotechnol. 2008 Aug;26(8):925-32
pubmed: 18641636
MAbs. 2016 May-Jun;8(4):659-71
pubmed: 27045800
Nat Rev Mater. 2016 Sep;1(9):
pubmed: 27668091
Drug Discov Today Technol. 2018 Dec;30:55-61
pubmed: 30553521