The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials.
bone morphogenic protein-2
bone morphogenic protein-4
bone regeneration
heparan sulfate
heparin
nanomaterial
osteogenic
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
12
2021
accepted:
13
04
2022
entrez:
1
6
2022
pubmed:
2
6
2022
medline:
2
6
2022
Statut:
epublish
Résumé
Bone regeneration in large segmental defects depends on the action of osteoblasts and the ingrowth of new blood vessels. Therefore, it is important to promote the release of osteogenic/angiogenic growth factors. Since the discovery of heparin, its anticoagulant, anti-inflammatory, and anticancer functions have been extensively studied for over a century. Although the application of heparin is widely used in the orthopedic field, its auxiliary effect on bone regeneration is yet to be unveiled. Specifically, approximately one-third of the transforming growth factor (TGF) superfamily is bound to heparin and heparan sulfate, among which TGF-β1, TGF-β2, and bone morphogenetic protein (BMP) are the most common growth factors used. In addition, heparin can also improve the delivery and retention of BMP-2
Identifiants
pubmed: 35646879
doi: 10.3389/fbioe.2022.837172
pii: 837172
pmc: PMC9133562
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
837172Informations de copyright
Copyright © 2022 Wang, Xiao, Wang, Zhang, Ma, Zhang and Wang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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