Regional Strain Score as Prognostic Marker of Cardiovascular Events From the Multi-Ethnic Study of Atherosclerosis (MESA).
Multi-Ethnic Study of Atherosclerosis (MESA)
cardiac magnetic resonance
coronary heart disease
heart failure
regional strain
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
07
02
2022
accepted:
25
04
2022
entrez:
1
6
2022
pubmed:
2
6
2022
medline:
2
6
2022
Statut:
epublish
Résumé
Left ventricular (LV) circumferential strain (Ecc) is an accurate indicator of regional myocardial function, particularly using the regional Ecc or layer-specific strain. This study aimed to investigate the prognostic value of a regional strain score (RSS) for predicting the incident of heart failure (HF) and coronary heart disease (CHD) in a population without a history of cardiovascular disease at baseline. Data from participants in the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent tagged magnetic resonance imaging for strain determination were analyzed. Using -17% and -10% as Ecc cut-offs, each segment was rated from 0 to 2 points according to the Ecc value of each layer. The endo-Ecc, mid-Ecc, and epi-Ecc values from the 16-segment model were used to calculate three RSS: Endo-, Mid-, and Epi-RSS, respectively, which were defined as a percentage of good LV regional function. The Intramyocardial-RSS was the sum of these three RSS. Cox proportional hazard models were used to evaluate the association between each RSS and incident HF and hard CHD. Among the 1,506 participants (63.3 ± 9.4 years, 54.6% men), 122 cases of hard CHD and 91 cases of HF were observed [median (IQR) follow-up 15.9 (12.9-16.6) years]. After adjustment, Mid-, Epi-, and Intramyocardial-RSS values <50% were independently associated with HF [adjusted HR 1.43; 95% CI (1.08-2.87), Layer-specific regional Ecc, assessed by RSS, provides a robust, independent predictive value for incident HF and hard CHD in asymptomatic participants without any history of previous clinical cardiovascular disease. Unique identifier: NCT00005487.
Sections du résumé
Background
UNASSIGNED
Left ventricular (LV) circumferential strain (Ecc) is an accurate indicator of regional myocardial function, particularly using the regional Ecc or layer-specific strain.
Aim
UNASSIGNED
This study aimed to investigate the prognostic value of a regional strain score (RSS) for predicting the incident of heart failure (HF) and coronary heart disease (CHD) in a population without a history of cardiovascular disease at baseline.
Materials and Methods
UNASSIGNED
Data from participants in the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent tagged magnetic resonance imaging for strain determination were analyzed. Using -17% and -10% as Ecc cut-offs, each segment was rated from 0 to 2 points according to the Ecc value of each layer. The endo-Ecc, mid-Ecc, and epi-Ecc values from the 16-segment model were used to calculate three RSS: Endo-, Mid-, and Epi-RSS, respectively, which were defined as a percentage of good LV regional function. The Intramyocardial-RSS was the sum of these three RSS. Cox proportional hazard models were used to evaluate the association between each RSS and incident HF and hard CHD.
Results
UNASSIGNED
Among the 1,506 participants (63.3 ± 9.4 years, 54.6% men), 122 cases of hard CHD and 91 cases of HF were observed [median (IQR) follow-up 15.9 (12.9-16.6) years]. After adjustment, Mid-, Epi-, and Intramyocardial-RSS values <50% were independently associated with HF [adjusted HR 1.43; 95% CI (1.08-2.87),
Conclusions
UNASSIGNED
Layer-specific regional Ecc, assessed by RSS, provides a robust, independent predictive value for incident HF and hard CHD in asymptomatic participants without any history of previous clinical cardiovascular disease.
Clinical Trial Registration
UNASSIGNED
Unique identifier: NCT00005487.
Identifiants
pubmed: 35647063
doi: 10.3389/fcvm.2022.870942
pmc: PMC9136083
doi:
Banques de données
ClinicalTrials.gov
['NCT00005487']
Types de publication
Journal Article
Langues
eng
Pagination
870942Informations de copyright
Copyright © 2022 Pezel, Bluemke, Wu, Lima and Ambale Venkatesh.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Circ Cardiovasc Imaging. 2009 Mar;2(2):116-22
pubmed: 19808577
J Cardiovasc Magn Reson. 2009 Dec 21;11:55
pubmed: 20025732
Eur Heart J Cardiovasc Imaging. 2019 Jun 1;20(6):605-619
pubmed: 30903139
Int J Cardiol. 2013 Jun 5;166(1):85-9
pubmed: 22071039
JACC Heart Fail. 2016 Apr;4(4):237-48
pubmed: 26682794
J Am Soc Echocardiogr. 2016 May;29(5):412-20
pubmed: 26969138
Eur Cardiol. 2020 Apr 04;15:e13
pubmed: 32373186
Circulation. 2003 Aug 26;108(8):977-82
pubmed: 12912813
J Am Coll Cardiol. 2008 Dec 16;52(25):2148-55
pubmed: 19095132
Br Heart J. 1981 Mar;45(3):248-63
pubmed: 7008815
J Am Coll Cardiol. 2010 Nov 23;56(22):1812-22
pubmed: 21087709
IEEE Trans Med Imaging. 2000 Mar;19(3):186-202
pubmed: 10875703
Circ Cardiovasc Imaging. 2021 Jun;14(6):e012459
pubmed: 34126756
J Am Coll Cardiol. 2009 Aug 11;54(7):618-24
pubmed: 19660692
JACC Cardiovasc Imaging. 2015 May;8(5):540-549
pubmed: 25890580
Circulation. 2008 Dec 9;118(24):2571-87
pubmed: 19064692
Circ Cardiovasc Imaging. 2009 May;2(3):191-8
pubmed: 19808592
Radiology. 2019 Oct;293(1):107-114
pubmed: 31453766
JACC Cardiovasc Imaging. 2021 Jun;14(6):1177-1188
pubmed: 33454266
Am J Epidemiol. 2002 Nov 1;156(9):871-81
pubmed: 12397006
JACC Cardiovasc Imaging. 2021 May;14(5):1038-1052
pubmed: 32828781
Circulation. 2020 Mar 3;141(9):e139-e596
pubmed: 31992061
J Cardiovasc Magn Reson. 2005;7(5):783-91
pubmed: 16358393
Eur Heart J. 2021 Sep 21;42(36):3599-3726
pubmed: 34447992
J Cardiovasc Magn Reson. 2020 Dec 3;22(1):81
pubmed: 33267877
Circulation. 2000 Mar 7;101(9):981-8
pubmed: 10704164
J Magn Reson Imaging. 2015 Jul;42(1):153-9
pubmed: 25223588
Circulation. 2002 Jan 29;105(4):539-42
pubmed: 11815441
Eur Heart J. 2008 May;29(10):1283-9
pubmed: 18385117
Eur Heart J. 2013 Aug;34(30):2354-61
pubmed: 23644181