The Potential of Sewage Sludge to Predict and Evaluate the Human Chemical Exposome.
Journal
Environmental science & technology letters
ISSN: 2328-8930
Titre abrégé: Environ Sci Technol Lett
Pays: United States
ID NLM: 101628367
Informations de publication
Date de publication:
14 Dec 2021
14 Dec 2021
Historique:
received:
19
10
2021
revised:
05
11
2021
accepted:
08
11
2021
entrez:
1
6
2022
pubmed:
2
6
2022
medline:
2
6
2022
Statut:
ppublish
Résumé
Chemicals are part of our daily lives, and we are exposed to numerous chemicals through multiple pathways. Relevant scientific evidence contributing to the regulation of hazardous chemicals require a holistic approach to assess simultaneous exposure to multiple compounds. Biomonitoring provides an accurate estimation of exposure to chemicals through very complex and costly sampling campaigns. Finding efficient proxies to predict the risk of chemical exposure in humans is an urgent need to cover large areas and populations at a reasonable cost. We conducted an exploratory study to characterize the human chemical exposome in maternal blood and placenta samples of a population-based birth cohort in Barcelona (2018-2021). Ultimate HRMS-based approaches were applied including wide-scope target, suspect, and nontarget screening. Forty-two chemicals were identified including pesticides, personal care products, or industrial compounds, among others, in the range of ng/mL and ng/g. In parallel, sewage sludge from the wastewater treatment plants serving the residence areas of the studied population were also screened, showing correlations with the type and concentrations of chemicals found in humans. Our findings were suggestive for the potential use of sewage sludge as a proxy of the human exposure and its application in early warning systems to prevent bioaccumulation of hazardous chemicals.
Identifiants
pubmed: 35647215
doi: 10.1021/acs.estlett.1c00848
pmc: PMC9132361
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1077-1084Informations de copyright
© 2021 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Anal Chem. 2018 Mar 6;90(5):3156-3164
pubmed: 29381867
Sci Rep. 2014 Jan 16;4:3731
pubmed: 24429544
Environ Int. 2021 May;150:106404
pubmed: 33578067
Ann Glob Health. 2016 Jan-Feb;82(1):10-9
pubmed: 27325064
J Hazard Mater. 2019 Feb 5;363:277-285
pubmed: 30312924
Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50
pubmed: 16103423
J Am Soc Mass Spectrom. 2021 Jun 2;32(6):1412-1423
pubmed: 34027658
Environ Sci Technol. 2015 Oct 20;49(20):12333-41
pubmed: 26418421
Environ Sci Technol. 2018 Jun 19;52(12):6881-6894
pubmed: 29782800
BMC Bioinformatics. 2010 Jul 23;11:395
pubmed: 20650010
J Cheminform. 2016 Jan 29;8:3
pubmed: 26834843
Int J Gynaecol Obstet. 2015 Dec;131(3):219-25
pubmed: 26433469
Eur J Obstet Gynecol Reprod Biol. 1995 May;59 Suppl:S47-54
pubmed: 7556823
J Hazard Mater. 2021 Jan 5;401:123272
pubmed: 32645544
Eur Respir Rev. 2015 Mar;24(135):92-101
pubmed: 25726560
Environ Res. 2019 Oct;177:108648
pubmed: 31421451
Environ Health. 2017 Jul 28;16(1):82
pubmed: 28754128
Environ Int. 2021 Jan;146:106082
pubmed: 33227583
Environ Sci Technol. 2021 Apr 20;55(8):5037-5049
pubmed: 33726493
Environ Int. 2020 Jun;139:105545
pubmed: 32361063
J Hazard Mater. 2021 Jan 5;401:123377
pubmed: 32652425
Regul Toxicol Pharmacol. 2021 Aug;124:104978
pubmed: 34174381
Nat Methods. 2019 Apr;16(4):299-302
pubmed: 30886413
MethodsX. 2021 Jan 05;8:101193
pubmed: 34434720
Nucleic Acids Res. 2007 Jan;35(Database issue):D521-6
pubmed: 17202168
Water Res. 2021 May 1;195:116983
pubmed: 33721674
Environ Sci Technol. 2021 Jun 1;55(11):7365-7375
pubmed: 34006107
PLoS One. 2016 Apr 22;11(4):e0154387
pubmed: 27105432
Talanta. 2021 Apr 1;225:121979
pubmed: 33592727
Sci Total Environ. 2010 Jan 15;408(4):790-5
pubmed: 19900697
J Hazard Mater. 2020 Apr 5;387:121712
pubmed: 31784138
Front Cell Neurosci. 2015 Apr 10;9:124
pubmed: 25914621
Clin Chem Lab Med. 2017 Mar 1;55(3):415-423
pubmed: 27559692
Environ Health Perspect. 2016 Aug 1;124(8):A137-40
pubmed: 27479988
Eur J Cancer Prev. 2019 Jul;28(4):344-349
pubmed: 30362975
Environ Sci Technol. 2014 Feb 18;48(4):2097-8
pubmed: 24476540
Environ Int. 2021 Jun;151:106415
pubmed: 33706127
Sci Rep. 2019 Mar 14;9(1):4565
pubmed: 30872659
Sci Total Environ. 2021 Dec 10;799:149230
pubmed: 34364275