Association between ABO and RH blood groups and Hepatitis B virus infection among young Nigerian adults.
ABO
Adolescents
Blood groups
Hepatitis B Virus
Nigeria
Rh antigen
Journal
Journal of preventive medicine and hygiene
ISSN: 2421-4248
Titre abrégé: J Prev Med Hyg
Pays: Italy
ID NLM: 9214440
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
14
01
2022
accepted:
16
03
2022
entrez:
1
6
2022
pubmed:
2
6
2022
medline:
7
6
2022
Statut:
epublish
Résumé
Several diseases are reported to be associated with ABO/Rh blood groups. Data on the association between ABO and Rh D blood group antigens in the Nigerian population is sparse. This study aimed at determining the prevalence of Hepatitis B Virus (HBV) infection as well as its association with ABO and Rh D antigens among young Nigerian adults. Whole blood was collected from 496 students and screened for the presence of HBsAg using an immuno-chromatographic technique. The ABO and Rh D antigen status of participants were also determined using standard techniques. In this study, the prevalence of HBV infection was 10/496 (2.10%). Of all factors assessed, only age of participants was identified as a risk factor (P < 0.05) for HBV seropositivity. Over half 257/496 (51.5%) of subjects were of the blood group O type, while 18/496 (3.6%) were of the AB blood type which was the least in occurrence. Rh D negative blood group was observed among 24/496 (4.8%) subjects. Those with the B blood type were observed to have an insignificantly (P > 0.05) higher prevalence of HBV infection. However, with respect to Rh D antigen alone, participants negative for the antigen were observed to have a five times higher risk of acquiring HBV infection than those positive for it (OR = 5.273, 95% CI = 1.056, 26.321, P > 0.05). Combining the ABO and Rh blood group systems, an association (OR = 20.174; P > 0.05) was found to exist between B Rh D negative status and HBV infection. Possession of B antigen without Rh D antigen is associated with increased risk of acquiring HBV infection.
Sections du résumé
Background
UNASSIGNED
Several diseases are reported to be associated with ABO/Rh blood groups. Data on the association between ABO and Rh D blood group antigens in the Nigerian population is sparse. This study aimed at determining the prevalence of Hepatitis B Virus (HBV) infection as well as its association with ABO and Rh D antigens among young Nigerian adults.
Methods
UNASSIGNED
Whole blood was collected from 496 students and screened for the presence of HBsAg using an immuno-chromatographic technique. The ABO and Rh D antigen status of participants were also determined using standard techniques.
Results
UNASSIGNED
In this study, the prevalence of HBV infection was 10/496 (2.10%). Of all factors assessed, only age of participants was identified as a risk factor (P < 0.05) for HBV seropositivity. Over half 257/496 (51.5%) of subjects were of the blood group O type, while 18/496 (3.6%) were of the AB blood type which was the least in occurrence. Rh D negative blood group was observed among 24/496 (4.8%) subjects. Those with the B blood type were observed to have an insignificantly (P > 0.05) higher prevalence of HBV infection. However, with respect to Rh D antigen alone, participants negative for the antigen were observed to have a five times higher risk of acquiring HBV infection than those positive for it (OR = 5.273, 95% CI = 1.056, 26.321, P > 0.05). Combining the ABO and Rh blood group systems, an association (OR = 20.174; P > 0.05) was found to exist between B Rh D negative status and HBV infection.
Conclusion
UNASSIGNED
Possession of B antigen without Rh D antigen is associated with increased risk of acquiring HBV infection.
Identifiants
pubmed: 35647381
doi: 10.15167/2421-4248/jpmh2022.63.1.1967
pmc: PMC9121686
doi:
Substances chimiques
ABO Blood-Group System
0
Hepatitis B Surface Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
E109-E114Informations de copyright
©2022 Pacini Editore SRL, Pisa, Italy.
Déclaration de conflit d'intérêts
Conflict of interest statement Authors have no conflict of interest to declare.
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