Valuable effect of Manuka Honey in increasing the printability and chondrogenic potential of a naturally derived bioink.
Articular cartilage
Extrusion bioprinting
Manuka honey
Mesenchymal stem cells
Methacrylated gellan gum
Journal
Materials today. Bio
ISSN: 2590-0064
Titre abrégé: Mater Today Bio
Pays: England
ID NLM: 101757228
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
17
02
2022
revised:
07
05
2022
accepted:
09
05
2022
entrez:
1
6
2022
pubmed:
2
6
2022
medline:
2
6
2022
Statut:
epublish
Résumé
Hydrogel-based bioinks are the main formulations used for Articular Cartilage (AC) regeneration due to their similarity to chondral tissue in terms of morphological and mechanical properties. However, the main challenge is to design and formulate bioinks able to allow reproducible additive manufacturing and fulfil the biological needs for the required tissue. In our work, we investigated an innovative Manuka honey (MH)-loaded photocurable gellan gum methacrylated (GGMA) bioink, encapsulating mesenchymal stem cells differentiated in chondrocytes (MSCs-C), to generate 3D bioprinted construct for AC studies. We demonstrated the beneficial effect of MH incorporation on the bioink printability, leading to the obtainment of a more homogenous filament extrusion and therefore a better printing resolution. Also, GGMA-MH formulation showed higher viscoelastic properties, presenting complex modulus G∗ values of ∼1042 Pa, compared to ∼730 Pa of GGMA. Finally, MH-enriched bioink induced a higher expression of chondrogenic markers
Identifiants
pubmed: 35647514
doi: 10.1016/j.mtbio.2022.100287
pii: S2590-0064(22)00085-0
pmc: PMC9130107
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100287Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Annachiara Scalzone reports financial support was provided by 10.13039/501100000266Engineering and Physical Sciences Research Council. Kenny Dalgarno, Xiao Nong Wang reports financial support was provided by 10.13039/501100012041Versus Arthritis.
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