A Two Amino Acid Duplication, L167E168, in the Ω-Loop Drastically Decreases Carbapenemase Activity of KPC-53, a Natural Class A β-Lactamase.
KPC-53
carbapenemase
serine-β-lactamase
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
21 06 2022
21 06 2022
Historique:
pubmed:
2
6
2022
medline:
24
6
2022
entrez:
1
6
2022
Statut:
ppublish
Résumé
KPC-53 enzyme is a natural KPC variant which showed a duplication of L167E168 residues in the Ω-loop structure. The
Identifiants
pubmed: 35647648
doi: 10.1128/aac.02402-21
pmc: PMC9211410
doi:
Substances chimiques
Amino Acids
0
Anti-Bacterial Agents
0
Azabicyclo Compounds
0
Bacterial Proteins
0
Drug Combinations
0
beta-Lactamase Inhibitors
0
beta-Lactamases
EC 3.5.2.6
carbapenemase
EC 3.5.2.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0240221Références
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