Maternal condyloma acuminata infection in pregnancy and offspring long-term respiratory and infectious outcome.
Condyloma acuminata
Infectious morbidity
Long-term morbidity
Pregnancy
Respiratory morbidity
Journal
Archives of gynecology and obstetrics
ISSN: 1432-0711
Titre abrégé: Arch Gynecol Obstet
Pays: Germany
ID NLM: 8710213
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
03
01
2022
accepted:
14
05
2022
medline:
19
4
2023
pubmed:
2
6
2022
entrez:
1
6
2022
Statut:
ppublish
Résumé
Maternal condyloma acuminata infection may be vertically transmitted to the offspring during pregnancy and childbirth. Our study aimed to investigate the possible impact of maternal condyloma acuminata infection in pregnancy on offspring respiratory and infectious morbidity. A population-based cohort analysis including all singleton deliveries occurring between 1991 and 2014 at a tertiary medical center. Long-term infectious and respiratory morbidities were compared between children with and without exposure to maternal condyloma infection during pregnancy. A Kaplan-Meier survival curve was used to compare cumulative hospitalization rate and a Cox regression analyses to control for confounders. No significant differences were found in total respiratory and infectious related hospitalizations between the study groups. The survival curves demonstrated no difference in the cumulative incidence between the two groups in both respiratory hospitalizations (log-rank, p = 0.18) and infectious hospitalizations (log-rank, p = 0.95). Cox multivariable analyses demonstrated that exposure to maternal condyloma infection during pregnancy is not a risk factor for neither infectious (aHR 0.91, [CI] 0.49-1.69) nor respiratory (aHR 0.37, [CI] 0.09-1.51) morbidity during childhood and adolescence. Exposure to maternal condyloma infection during pregnancy does not appear to be an independent risk factor for later respiratory or infectious morbidity throughout childhood and adolescence.
Sections du résumé
BACKGROUND
Maternal condyloma acuminata infection may be vertically transmitted to the offspring during pregnancy and childbirth. Our study aimed to investigate the possible impact of maternal condyloma acuminata infection in pregnancy on offspring respiratory and infectious morbidity.
METHODS
A population-based cohort analysis including all singleton deliveries occurring between 1991 and 2014 at a tertiary medical center. Long-term infectious and respiratory morbidities were compared between children with and without exposure to maternal condyloma infection during pregnancy. A Kaplan-Meier survival curve was used to compare cumulative hospitalization rate and a Cox regression analyses to control for confounders.
RESULTS
No significant differences were found in total respiratory and infectious related hospitalizations between the study groups. The survival curves demonstrated no difference in the cumulative incidence between the two groups in both respiratory hospitalizations (log-rank, p = 0.18) and infectious hospitalizations (log-rank, p = 0.95). Cox multivariable analyses demonstrated that exposure to maternal condyloma infection during pregnancy is not a risk factor for neither infectious (aHR 0.91, [CI] 0.49-1.69) nor respiratory (aHR 0.37, [CI] 0.09-1.51) morbidity during childhood and adolescence.
CONCLUSION
Exposure to maternal condyloma infection during pregnancy does not appear to be an independent risk factor for later respiratory or infectious morbidity throughout childhood and adolescence.
Identifiants
pubmed: 35648228
doi: 10.1007/s00404-022-06631-z
pii: 10.1007/s00404-022-06631-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1423-1429Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Fernandes JV, Galvão de Araújo JM, Araújo A, de Medeiros FT (2013) Biology and natural history of human papillomavirus infection. Open Access J Clin Trials. https://doi.org/10.2147/OAJCT.S37741
doi: 10.2147/OAJCT.S37741
Hawkins MG, Winder DM, Ball SLR et al (2013) Detection of specific HPV subtypes responsible for the pathogenesis of condylomata acuminata. Virol J 10:137. https://doi.org/10.1186/1743-422X-10-137
doi: 10.1186/1743-422X-10-137
pubmed: 23634957
pmcid: 3658907
Yanofsky VR, Patel RV, Goldenberg G (2012) Genital warts: a comprehensive review. J Clin Aesthet Dermatol 5:25–36
pubmed: 22768354
pmcid: 3390234
Liu P, Xu L, Sun Y, Wang Z (2014) The prevalence and risk of human papillomavirus infection in pregnant women. Epidemiol Infect 142:1567–1578. https://doi.org/10.1017/S0950268814000636
doi: 10.1017/S0950268814000636
pubmed: 24667102
Lugović-Mihić L, Cvitanović H, Djaković I et al (2021) The influence of psychological stress on HPV infection manifestations and carcinogenesis. Cell Physiol Biochem 55:71–88. https://doi.org/10.33594/000000395
doi: 10.33594/000000395
pubmed: 34242500
Ambühl LMM, Baandrup U, Dybkær K et al (2016) Human papillomavirus infection as a possible cause of spontaneous abortion and spontaneous preterm delivery. Infect Dis Obstet Gynecol 2016:3086036. https://doi.org/10.1155/2016/3086036
doi: 10.1155/2016/3086036
pubmed: 27110088
pmcid: 4826700
Cho G, Min K-J, Hong H-R et al (2013) High-risk human papillomavirus infection is associated with premature rupture of membranes. BMC Pregnancy Childbirth 13:173. https://doi.org/10.1186/1471-2393-13-173
doi: 10.1186/1471-2393-13-173
pubmed: 24011340
pmcid: 3846597
Nimrodi M, Kleitman V, Wainstock T et al (2018) The association between cervical inflammation and histologic evidence of HPV in PAP smears and adverse pregnancy outcome in low risk population. Eur J Obstet Gynecol Reprod Biol 225:160–165. https://doi.org/10.1016/j.ejogrb.2018.04.023
doi: 10.1016/j.ejogrb.2018.04.023
pubmed: 29727786
Cohen E, Levy A, Holcberg G et al (2011) Perinatal outcomes in condyloma acuminata pregnancies. Arch Gynecol Obstet 283:1269–1273. https://doi.org/10.1007/s00404-010-1558-2
doi: 10.1007/s00404-010-1558-2
pubmed: 20556405
Merckx M, Liesbeth W-VW, Arbyn M et al (2013) Transmission of carcinogenic human papillomavirus types from mother to child: a meta-analysis of published studies. Eur J Cancer Prev 22:277–285. https://doi.org/10.1097/CEJ.0b013e3283592c46
doi: 10.1097/CEJ.0b013e3283592c46
pubmed: 22990004
Park H, Lee SW, Lee IH et al (2012) Rate of vertical transmission of human papillomavirus from mothers to infants: relationship between infection rate and mode of delivery. Virol J 9:80. https://doi.org/10.1186/1743-422X-9-80
doi: 10.1186/1743-422X-9-80
pubmed: 22497663
pmcid: 3420243
Chatzistamatiou K, Sotiriadis A, Agorastos T (2016) Effect of mode of delivery on vertical human papillomavirus transmission - a meta-analysis. J Obstet Gynaecol 36:10–14. https://doi.org/10.3109/01443615.2015.1030606
doi: 10.3109/01443615.2015.1030606
pubmed: 26367314
Niyibizi J, Rodier C, Wassef M, Trottier H (2014) Risk factors for the development and severity of juvenile-onset recurrent respiratory papillomatosis: a systematic review. Int J Pediatr Otorhinolaryngol 78:186–197. https://doi.org/10.1016/j.ijporl.2013.11.036
doi: 10.1016/j.ijporl.2013.11.036
pubmed: 24367938
Zouridis A, Kalampokas T, Panoulis K et al (2018) Intrauterine HPV transmission: a systematic review of the literature. Arch Gynecol Obstet 298:35–44. https://doi.org/10.1007/s00404-018-4787-4
doi: 10.1007/s00404-018-4787-4
pubmed: 29777347
Ambühl LMM, Leonhard AK, Widen Zakhary C et al (2017) Human papillomavirus infects placental trophoblast and Hofbauer cells, but appears not to play a causal role in miscarriage and preterm labor. Acta Obstet Gynecol Scand 96:1188–1196. https://doi.org/10.1111/aogs.13190
doi: 10.1111/aogs.13190
pubmed: 28699189
Sarkola ME, Grénman SE, Rintala MAM et al (2008) Human papillomavirus in the placenta and umbilical cord blood. Acta Obstet Gynecol Scand 87:1181–1188. https://doi.org/10.1080/00016340802468308
doi: 10.1080/00016340802468308
pubmed: 18972230
Workowski KA, Bolan GA, Centers for Disease Control and Prevention (2015) Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep 64:1–137
pubmed: 26042815
Shah KV (2014) A case for immunization of human papillomavirus (HPV) 6/11-infected pregnant women with the quadrivalent HPV vaccine to prevent juvenile-onset laryngeal papilloma. J Infect Dis 209:1307–1309. https://doi.org/10.1093/infdis/jit611
doi: 10.1093/infdis/jit611
pubmed: 24265442
Silverberg MJ, Thorsen P, Lindeberg H et al (2003) Condyloma in pregnancy is strongly predictive of juvenile-onset recurrent respiratory papillomatosis. Obstet Gynecol 101:645–652. https://doi.org/10.1016/s0029-7844(02)03081-8
doi: 10.1016/s0029-7844(02)03081-8
pubmed: 12681865
Central Bureau of Statistics. Localities in Israel 2008–2017. Available at: https://www.cbs.gov.il/en/mediarelease/Pages/2019/Localities-in-Israel-2008-2017.aspx . Accessed February 6, 2019
Lee SM, Park JS, Norwitz ER et al (2013) Risk of vertical transmission of human papillomavirus throughout pregnancy: a prospective study. PLoS ONE 8:e66368. https://doi.org/10.1371/journal.pone.0066368
doi: 10.1371/journal.pone.0066368
pubmed: 23785495
pmcid: 3681772
Sheiner E, Shoham-Vardi I, Weitzman D et al (1998) Decisions regarding pregnancy termination among Bedouin couples referred to third level ultrasound clinic. Eur J Obstet Gynecol Reprod Biol 76:141–146. https://doi.org/10.1016/s0301-2115(97)00178-4
doi: 10.1016/s0301-2115(97)00178-4
pubmed: 9481563
Abu-Ghanem S, Sheiner E, Sherf M et al (2012) Lack of prenatal care in a traditional community: trends and perinatal outcomes. Arch Gynecol Obstet 285:1237–1242. https://doi.org/10.1007/s00404-011-2153-x
doi: 10.1007/s00404-011-2153-x
pubmed: 22124534
Amir H, Abokaf H, Levy YA et al (2018) Bedouin women’s gender preferences when choosing obstetricians and gynecologists. J Immigr Minor Health 20:51–58. https://doi.org/10.1007/s10903-016-0522-z
doi: 10.1007/s10903-016-0522-z
pubmed: 27796701
Estis-Deaton A, Sheiner E, Wainstock T et al (2017) The association between inadequate prenatal care and future healthcare use among offspring in the Bedouin population. Int J Gynaecol Obstet 139:284–289. https://doi.org/10.1002/ijgo.12314
doi: 10.1002/ijgo.12314
pubmed: 28857159
Gutvirtz G, Wainstock T, Landau D, Sheiner E (2020) Unplanned out-of-Hospital birth-short and long-term consequences for the offspring. J Clin Med. https://doi.org/10.3390/jcm9020339
doi: 10.3390/jcm9020339
pubmed: 32521764
pmcid: 7356322
Trottier H, Franco EL (2006) The epidemiology of genital human papillomavirus infection. Vaccine 24(Suppl 1):S1-15. https://doi.org/10.1016/j.vaccine.2005.09.054
doi: 10.1016/j.vaccine.2005.09.054
pubmed: 16406226
Feldman JG, Chirgwin K, Dehovitz JA, Minkoff H (1997) The association of smoking condyloma acuminatum in and risk of women. Obstet Gynecol 89(3):346–350
doi: 10.1016/S0029-7844(97)00011-2
pubmed: 9052582
Dan N, Sheiner E, Wainstock T et al (2021) Maternal smoking during pregnancy and the risk for childhood infectious diseases in the offspring: a population-based cohort study. Am J Perinatol 38:166–170. https://doi.org/10.1055/s-0039-1695773
doi: 10.1055/s-0039-1695773
pubmed: 31491797
Wangu Z, Hsu KK (2016) Impact of HPV vaccination on anogenital warts and respiratory papillomatosis. Hum Vaccin Immunother 12:1357–1362. https://doi.org/10.1080/21645515.2016.1172754
doi: 10.1080/21645515.2016.1172754
pubmed: 27217191
pmcid: 5036961
Novakovic D, Cheng ATL, Zurynski Y et al (2018) A prospective study of the incidence of juvenile-onset recurrent respiratory papillomatosis after implementation of a national HPV vaccination program. J Infect Dis 217:208–212. https://doi.org/10.1093/infdis/jix498
doi: 10.1093/infdis/jix498
pubmed: 29136168
Yang L-J, Zhu D-N, Dang Y-L, Zhao X (2016) Treatment of condyloma acuminata in pregnant women with cryotherapy combined with proanthocyanidins: outcome and safety. Exp Ther Med 11:2391–2394. https://doi.org/10.3892/etm.2016.3207
doi: 10.3892/etm.2016.3207
pubmed: 27284325
pmcid: 4887779
Arena S, Marconi M, Villani C (2001) Pregnancy and condyloma. Evaluation about therapeutic effectiveness of laser CO
pubmed: 11723423
Kodner CM, Nasraty S (2004) Management of genital warts. Am Fam Physician 70:2335–2342
pubmed: 15617297
Tasca RA, Clarke RW (2006) Recurrent respiratory papillomatosis. Arch Dis Child 91:689–691. https://doi.org/10.1136/adc.2005.090514
doi: 10.1136/adc.2005.090514
pubmed: 16861486
pmcid: 2083023
Shah K, Kashima H, Polk BF et al (1986) Rarity of cesarean delivery in cases of juvenile-onset respiratory papillomatosis. Obstet Gynecol 68:795–799
pubmed: 3785792
Loyo M, Pai SI, Netto GJ, Tunkel DE (2008) Aggressive recurrent respiratory papillomatosis in a neonate. Int J Pediatr Otorhinolaryngol 72:917–920. https://doi.org/10.1016/j.ijporl.2008.02.022
doi: 10.1016/j.ijporl.2008.02.022
pubmed: 18423627
Kosko JR, Derkay CS (1996) Role of cesarean section in prevention of recurrent respiratory papillomatosis - Is there one? Int J Pediatr Otorhinolaryngol Otorhinolaryngol 35(1):31–38
doi: 10.1016/0165-5876(95)01279-6
Sinal SH, Woods CR (2005) Human papillomavirus infections of the genital and respiratory tracts in young children. Semin Pediatr Infect Dis 16:306–316. https://doi.org/10.1053/j.spid.2005.06.010
doi: 10.1053/j.spid.2005.06.010
pubmed: 16210110
Gilson R, Nugent D, Niklas Werner R et al (2019) European guideline for the management of anogenital warts. J Eur Acad Dermatol Venereol 34(8):1644–1653
doi: 10.1111/jdv.16522
Moriña D, Fernández-Fontelo A, Cabaña A et al (2021) Quantifying the under-reporting of uncorrelated longitudal data: the genital warts example. BMC Med Res Methodol 21:6. https://doi.org/10.1186/s12874-020-01188-4
doi: 10.1186/s12874-020-01188-4
pubmed: 33407173
pmcid: 7789373