Efficacy of simvastatin in bone regeneration after surgical removal of mandibular third molars.
Bone morphogenetic protein
Gelatin sponge
Simvastatin
Journal
Oral and maxillofacial surgery
ISSN: 1865-1569
Titre abrégé: Oral Maxillofac Surg
Pays: Germany
ID NLM: 101319632
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
06
02
2021
accepted:
26
05
2022
medline:
28
8
2023
pubmed:
2
6
2022
entrez:
1
6
2022
Statut:
ppublish
Résumé
The aim of this study was to assess the efficacy of simvastatin in bone regeneration in extraction sockets of mandibular third molars using cone beam computed tomography (CBCT) at 6th post-operative month. This is a prospective randomized split-mouth study involving 15 patients who underwent surgical extraction of bilaterally impacted mandibular third molars with similar morphology on the same day. The efficacy of drug was analyzed by implanting 10 mg of simvastatin into the socket (study site) and observations were made over 6 months to compare the healing with the control site. The study results demonstrated a statistically significant difference in bone regeneration: mean gray value of 429.133 in study site compared with mean gray value of 310.153 in the control site. These values demonstrate significant change in bone regeneration in simvastatin site as compared to that of control site.
Identifiants
pubmed: 35648294
doi: 10.1007/s10006-022-01081-y
pii: 10.1007/s10006-022-01081-y
doi:
Substances chimiques
Simvastatin
AGG2FN16EV
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
427-432Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Bergman P, Linde C, Pütsep K, Pohanka A, Normark S, Henriques-Normark B et al (2011) Studies on the antibacterial effects of statins - in vitro and in vivo. PLoS ONE 6(8):e24394. https://doi.org/10.1371/journal.pone.0024394
doi: 10.1371/journal.pone.0024394
pubmed: 21912631
pmcid: 3166163
Chauhan AS, Maria A, Managutti A (2015) Efficacy of simvastatin in bone regeneration after surgical removal of mandibular third molars: a clinical pilot study. Journal of maxillofacial and oral surgery 14(3):578–585
doi: 10.1007/s12663-014-0697-6
pubmed: 26225047
Degala S, Bathija NA (2018) Evaluation of the efficacy of simvastatin in bone regeneration after surgical removal of bilaterally impacted third molars-a split-mouth randomized clinical trial. J Oral Maxillofac Surg 76(9):1847–1858. https://doi.org/10.1016/j.joms.2018.04.035
doi: 10.1016/j.joms.2018.04.035
pubmed: 29859160
Encarnação IC, Xavier CC, Bobinski F et al (2016) Analysis of bone repair and inflammatory process caused by simvastatin combined with PLGA+ HA+ βTCP Scaffold. Implant Dent 25(1):140–148
doi: 10.1097/ID.0000000000000359
pubmed: 26606285
Gutierrez GE, Lalka D, Garrett IR et al (2006) Transdermal application of lovastatin to rats causes profound increases in bone formation and plasma concentrations. Osteoporos Int 17(7):1033–1042
doi: 10.1007/s00198-006-0079-0
pubmed: 16758140
Kalfas IH (2001) Principles of bone healing. Neurosurg Focus 10(4):1–4
doi: 10.3171/foc.2001.10.4.2
Mouhamed AL, Mouhamed AI, Sadek H (2009) Evaluation of the outcome of adding biological modifier (simvastatin) to bone grafting material. Int J Oral Maxillofac Surg 38(5):455
doi: 10.1016/j.ijom.2009.03.210
Mundy G, Garrett R, Harris S et al (1999) Stimulation of bone formation in vitro and in rodents by statins. Science 286:1946–1949 [PubMed: 10583956]
doi: 10.1126/science.286.5446.1946
pubmed: 10583956
Pauly S, Luttosch F, Morawski M et al (2009) Simvastatin locally applied from a biodegradable coating of osteosynthetic implants improves fracture healing comparable to BMP-2 application. Bone 45(3):505–511
doi: 10.1016/j.bone.2009.05.010
pubmed: 19464400
Rosselli JE, Martins DM, Martins JL et al (2014) The effect of simvastatin on the regeneration of surgical cavities in the femurs of rabbits. Acta cirurgica brasileira 29(2):87–92
doi: 10.1590/S0102-86502014000200003
pubmed: 24604311
Saifi AM, Giraddi GB, Ahmed N (2017) Healing of extraction socket following local application of simvastatin: a split mouth prospective study. Journal of oral biology and craniofacial research 7(2):106–112
doi: 10.1016/j.jobcr.2017.04.001
pubmed: 28706784
pmcid: 5497393
Shah SR, Werlang CA, Kasper FK et al (2014) Novel applications of statins for bone regeneration. Natl Sci Rev 2(1):85–99
doi: 10.1093/nsr/nwu028
pubmed: 26543666
Stein D, Lee Y, Schmid MJ et al (2005) Local simvastatin effects on mandibular bone growth and inflammation. J Periodontol 76(11):1861–1870
doi: 10.1902/jop.2005.76.11.1861
pubmed: 16274305
pmcid: 1350642
Tanigo T, Takaoka R, Tabata Y (2010) Sustained release of water-insoluble simvastatin from biodegradable hydrogel augments bone regeneration. J Control Release 143(2):201–206
doi: 10.1016/j.jconrel.2009.12.027
pubmed: 20060429