The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance.

Animals Ion Channels / genetics Mice Physical Functional Performance Stress, Mechanical Tendons / metabolism Transcription Factors

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
06 2022
Historique:
entrez: 1 6 2022
pubmed: 2 6 2022
medline: 7 6 2022
Statut: ppublish

Résumé

How mechanical stress affects physical performance via tendons is not fully understood. Piezo1 is a mechanosensitive ion channel, and E756del

Identifiants

DOI: 10.1126/scitranslmed.abj5557 PMID: 35648809
pubmed: 35648809
doi: 10.1126/scitranslmed.abj5557
doi:

Substances chimiques

Ion Channels 0
Piezo1 protein, mouse 0
Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabj5557

Auteurs

Ryo Nakamichi (R)

Department of Molecular Medicine, Scripps Research, 10550 North Torrey Pines Road, MBB-102, La Jolla, CA 92037, USA.
Department of Systems BioMedicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo 113-8510, Japan.
Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.
ORCID: 0000-0002-0145-2135

Shang Ma (S)

Howard Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, 92037, USA.
Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA.

Takayuki Nonoyama (T)

Faculty of Advanced Life Science and Global Station for Soft Matter, Global Institution for Collaborative Research and Education (GSS, GI-CoRE), Hokkaido University, Sapporo 001-0021, Japan.
ORCID: 0000-0001-8554-0636

Tomoki Chiba (T)

Department of Systems BioMedicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo 113-8510, Japan.
ORCID: 0000-0001-5472-9030

Ryota Kurimoto (R)

Department of Systems BioMedicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo 113-8510, Japan.
ORCID: 0000-0003-3029-5287

Hiroki Ohzono (H)

Department of Molecular Medicine, Scripps Research, 10550 North Torrey Pines Road, MBB-102, La Jolla, CA 92037, USA.
ORCID: 0000-0001-7170-5401

Merissa Olmer (M)

Department of Molecular Medicine, Scripps Research, 10550 North Torrey Pines Road, MBB-102, La Jolla, CA 92037, USA.
ORCID: 0000-0002-2483-4216

Chisa Shukunami (C)

Department of Molecular Biology and Biochemistry and Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
ORCID: 0000-0001-5616-6761

Noriyuki Fuku (N)

Graduate School of Health and Sports Science, Juntendo University, Chiba 270-1965, Japan.
ORCID: 0000-0001-7792-5835

Guan Wang (G)

School of Sport and Health Sciences, University of Brighton, Brighton BN2 4AT, UK.
Centre for Regenerative Medicine and Devices, University of Brighton, Brighton BN2 4AT, UK.
ORCID: 0000-0002-7432-7933

Errol Morrison (E)

National Commission on Science and Technology, PCJ Building, 36 Trafalgar Road, Kingston 10, Jamaica.
ORCID: 0000-0003-2050-0064

Yannis P Pitsiladis (YP)

School of Sport and Health Sciences, University of Brighton, Brighton BN2 4AT, UK.
Centre of Stress and Age-related Disease, University of Brighton, Brighton BN2 4AT, UK.
ORCID: 0000-0001-6210-2449

Toshifumi Ozaki (T)

Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.
ORCID: 0000-0003-1732-9307

Darryl D'Lima (D)

Department of Molecular Medicine, Scripps Research, 10550 North Torrey Pines Road, MBB-102, La Jolla, CA 92037, USA.
ORCID: 0000-0002-8707-1455

Martin Lotz (M)

Department of Molecular Medicine, Scripps Research, 10550 North Torrey Pines Road, MBB-102, La Jolla, CA 92037, USA.
ORCID: 0000-0002-6299-8799

Ardem Patapoutian (A)

Howard Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, 92037, USA.
Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA.
ORCID: 0000-0003-0726-7034

Hiroshi Asahara (H)

Department of Molecular Medicine, Scripps Research, 10550 North Torrey Pines Road, MBB-102, La Jolla, CA 92037, USA.
Department of Systems BioMedicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo 113-8510, Japan.
ORCID: 0000-0002-5215-8745

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The mechanosensitive ion channel PIEZO1 is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › The mechanosensitive ion channel PIEZO1 is...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The mechanosensitive ion channel PIEZO1 is...
questionsmedicales.fr › Caractéristiques de la population › Santé › Aptitude physique › Performance fonctionnelle physique › The mechanosensitive ion channel PIEZO1 is...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Contrainte mécanique › The mechanosensitive ion channel PIEZO1 is...
questionsmedicales.fr › Appareil locomoteur › Tendons › The mechanosensitive ion channel PIEZO1 is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › The mechanosensitive ion channel PIEZO1 is...