Phosphatidylinositol transfer protein/planar cell polarity axis regulates neocortical morphogenesis by supporting interkinetic nuclear migration.
CP: Developmental biology
CP: Neuroscience
autism
convergent extension
interkinetic nuclear migration
morphogenesis
neocortex
neural stem cells
phosphatidylinositol transfer protein
planar cell polarity
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
31 05 2022
31 05 2022
Historique:
received:
15
03
2021
revised:
08
03
2022
accepted:
05
05
2022
entrez:
1
6
2022
pubmed:
2
6
2022
medline:
7
6
2022
Statut:
ppublish
Résumé
The neocortex expands explosively during embryonic development. The earliest populations of neural stem cells (NSCs) form a thin pseudostratified epithelium whose contour determines that of the adult neocortex. Neocortical complexity is accompanied by disproportional expansion of the NSC layer in its tangential dimension to increase tissue surface area. How such disproportional expansion is controlled remains unknown. We demonstrate that a phosphatidylinositol transfer protein (PITP)/non-canonical Wnt planar cell polarity (ncPCP) signaling axis promotes tangential expansion of developing neocortex. PITP signaling supports trafficking of specific ncPCP receptors from the NSC Golgi system to potentiate actomyosin activity important for cell-cycle-dependent interkinetic nuclear migration (IKNM). In turn, IKNM promotes lateral dispersion of newborn NSCs and tangential growth of the cerebral wall. These findings clarify functional roles for IKNM in NSC biology and identify tissue dysmorphogenesis resulting from impaired IKNM as a factor in autism risk, developmental brain disabilities, and neural tube birth defects.
Identifiants
pubmed: 35649377
pii: S2211-1247(22)00644-1
doi: 10.1016/j.celrep.2022.110869
pmc: PMC9230501
mid: NIHMS1812250
pii:
doi:
Substances chimiques
Phospholipid Transfer Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
110869Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM131804
Pays : United States
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
Références
Front Cell Neurosci. 2015 Jan 28;8:473
pubmed: 25674051
Med Image Comput Comput Assist Interv. 2009;12(Pt 2):617-24
pubmed: 20426163
Nat Protoc. 2018 Oct;13(10):2297-2311
pubmed: 30258174
J Cell Biol. 2005 Sep 12;170(6):935-45
pubmed: 16144905
Wiley Interdiscip Rev Dev Biol. 2018 Jan;7(1):
pubmed: 28906063
Development. 2014 Jun;141(11):2182-94
pubmed: 24866113
Nat Rev Mol Cell Biol. 2009 Nov;10(11):778-90
pubmed: 19851336
Dis Model Mech. 2014 Oct;7(10):1153-63
pubmed: 25128525
Am J Med Genet A. 2017 Jun;173(6):1473-1488
pubmed: 28440899
J Mol Neurosci. 2012 Mar;46(3):516-26
pubmed: 21881827
Curr Opin Cell Biol. 2018 Apr;51:110-116
pubmed: 29289896
Cereb Cortex. 1997 Oct-Nov;7(7):678-89
pubmed: 9373022
Nat Rev Neurosci. 2009 Oct;10(10):724-35
pubmed: 19763105
Curr Protoc Cytom. 2011 Jan;Chapter 7:Unit 7.38
pubmed: 21207361
Cell. 2009 Sep 18;138(6):1195-208
pubmed: 19766571
Annu Rev Pathol. 2019 Jan 24;14:293-318
pubmed: 30677308
J Biol Chem. 2000 Nov 3;275(44):34512-20
pubmed: 10944522
Semin Cell Dev Biol. 2020 Apr;100:199-211
pubmed: 31734039
Nat Neurosci. 2014 Nov;17(11):1528-35
pubmed: 25282615
J Cell Biol. 2014 Oct 27;207(2):171-9
pubmed: 25349257
Int Rev Cell Mol Biol. 2016;325:89-118
pubmed: 27241219
J Neurosci. 2010 Jul 14;30(28):9392-401
pubmed: 20631168
Mol Cell. 2008 Feb 1;29(2):191-206
pubmed: 18243114
PLoS One. 2014 Jan 07;9(1):e84472
pubmed: 24409301
BMC Bioinformatics. 2015 May 29;16:180
pubmed: 26022740
Dev Cell. 2018 Mar 26;44(6):725-740.e4
pubmed: 29587143
Biol Open. 2012 Dec 15;1(12):1200-3
pubmed: 23259054
Toxicol Pathol. 2017 Aug;45(6):705-744
pubmed: 28891434
Annu Rev Genomics Hum Genet. 2014;15:195-213
pubmed: 25184530
Cell. 2011 Jul 8;146(1):18-36
pubmed: 21729779
Cell Rep. 2016 Feb 9;14(5):991-999
pubmed: 26832401
Nat Rev Mol Cell Biol. 2017 Jun;18(6):375-388
pubmed: 28293032
Nucleic Acids Res. 2009 Jan;37(Database issue):D832-6
pubmed: 19015121
Annu Rev Cell Dev Biol. 2014;30:465-502
pubmed: 25000993
J Cell Sci. 2003 Sep 15;116(Pt 18):3677-85
pubmed: 12917355
Nat Neurosci. 2013 Nov;16(11):1556-66
pubmed: 24056697
Cell. 1991 Feb 22;64(4):789-800
pubmed: 1997207
J Invest Dermatol. 2009 Oct;129(10):2507-9
pubmed: 19357712
J Neurosci. 2002 Aug 1;22(15):6309-14
pubmed: 12151506
Nature. 2004 Jul 1;430(6995):93-8
pubmed: 15229603
Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16487-92
pubmed: 19805325
Trends Neurosci. 2020 Aug;43(8):608-621
pubmed: 32507511
Curr Opin Neurobiol. 2021 Feb;66:195-204
pubmed: 33412482
Development. 2011 Nov;138(22):5003-13
pubmed: 22028032
Biochem J. 2019 Aug 28;476(16):2321-2346
pubmed: 31462439
Hum Mol Genet. 2001 Oct 15;10(22):2593-601
pubmed: 11709546
J Lipid Res. 2019 Feb;60(2):269-275
pubmed: 30266835
J Lipid Res. 2019 Feb;60(2):242-268
pubmed: 30504233
Biochem J. 2003 Mar 1;370(Pt 2):551-6
pubmed: 12429016