Augmented anandamide signalling in the substantia nigra pars reticulata mediates panicolytic-like effects in mice confronted by Crotalus durissus terrificus pit vipers.
Anandamide
Crotalus durissus terrificus venomous pit viper
Panic attacks
Prey vs. venomous snake paradigm
Substantia nigra pars reticulata (SNpr)
URB597
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
25
05
2021
accepted:
26
03
2022
pubmed:
2
6
2022
medline:
20
8
2022
entrez:
1
6
2022
Statut:
ppublish
Résumé
The endocannabinoid modulation of fear and anxiety due to the on-demand synthesis and degradation is supported by a large body of research. Although it has been proposed that anandamide (AEA) in the substantia nigra pars reticulata (SNpr) seems to be important for the organisation of innate fear-related behaviours, a role for endogenous AEA has yet to be clarified. Mice were treated with the fatty acid amide hydrolase (FAAH) selective inhibitor URB597 at different concentrations (0.01, 0.1, 1 nmol/0.1 µL) in the SNpr and confronted by rattlesnakes (Crotalus durissus terrificus). The most effective dose of URB597 (1 nmol) was also preceded by microinjections of the CB URB597 (0.1 and 1 nmol) in the SNpr decreased the expression of defensive behaviours such as defensive attention, escape, and time spent inside the burrow of mice confronted by rattlesnakes. Moreover, pretreatment of SNpr with AM251 suppressed these antiaversive effects of URB597 in this midbrain structure. Overall, these data clearly indicate that the panicolytic consequences of endogenous AEA enhancement in the SNpr are mediated by CB1 receptor signalling.
Identifiants
pubmed: 35650304
doi: 10.1007/s00213-022-06127-3
pii: 10.1007/s00213-022-06127-3
doi:
Substances chimiques
Arachidonic Acids
0
Endocannabinoids
0
Polyunsaturated Alkamides
0
Receptor, Cannabinoid, CB1
0
anandamide
UR5G69TJKH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2753-2769Subventions
Organisme : Conselho Nacional de Pesquisa e Desenvolvimento Tecnológico
ID : 470119/2004-7
Organisme : Conselho Nacional de Pesquisa e Desenvolvimento Tecnológico
ID : 483763/2010-1
Organisme : Conselho Nacional de Pesquisa e Desenvolvimento Tecnológico
ID : 474853/2013-6
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2007/01174-1
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2012/03798-0
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2017/11855-8
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2018/03898-1
Organisme : Pro-Rectory of the University of São Paulo (USP) Research Grant
ID : IaPq2012-156-USP-12.1.25440.01.6
Organisme : German-Israeli Foundation for Scientific Research and Development
ID : I-1442-421.13/2017
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2020/15050-7
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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