Participation of lipopolysaccharide in hyperplasic adipose expansion: Involvement of NADPH oxidase/ROS/p42/p44 MAPK-dependent Cyclooxygenase-2.
COX-2
ROS
adipose tissue
lipopolysaccharide
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
11
05
2022
received:
31
10
2021
accepted:
20
05
2022
pubmed:
2
6
2022
medline:
16
7
2022
entrez:
1
6
2022
Statut:
ppublish
Résumé
Obesity is a world-wide problem, especially the child obesity, with the complication of various metabolic diseases. Child obesity can be developed as early as the age between 2 and 6. The expansion of fat mass in child age includes both hyperplasia and hypertrophy of adipose tissue, suggesting the importance of proliferation and adipogenesis of preadipocytes. The changed composition of gut microbiota is associated with obesity, revealing the roles of lipopolysaccharide (LPS) on manipulating adipose tissue development. Studies suggest that LPS enters the circulation and acts as a pro-inflammatory regulator to facilitate pathologies. Nevertheless, the underlying mechanisms behind LPS-modulated obesity are yet clearly elucidated. This study showed that LPS enhanced the expression of cyclooxygenase-2 (COX-2), an inflammatory regulator of obesity, in preadipocytes. Pretreating preadipocytes with the scavenger of reactive oxygen species (ROS) or the inhibitors of NADPH oxidase or p42/p44 MAPK markedly decreased LPS-stimulated gene expression of COX-2 together with the phosphorylation of p47
Identifiants
pubmed: 35650335
doi: 10.1111/jcmm.17419
pmc: PMC9279599
doi:
Substances chimiques
Lipopolysaccharides
0
Reactive Oxygen Species
0
Cyclooxygenase 2
EC 1.14.99.1
NADPH Oxidases
EC 1.6.3.-
Mitogen-Activated Protein Kinase 3
EC 2.7.11.24
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3850-3861Subventions
Organisme : Cathay General Hospital
ID : 103-CGH-FJU-01
Organisme : Cathay General Hospital
ID : 104-CGH-FJU-01
Organisme : Fu Jen Catholic University
ID : A0106010
Informations de copyright
© 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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