Evaluation of a Human T Cell-Targeted Multi-Epitope Vaccine for Q Fever in Animal Models of
ChAdOx2
Coxiella burnetii
Q fever
T cell vaccine
interferon gamma (IFNγ)
modified vaccinia Ankara (MVA)
multi-epitope vaccine
non-human primate (NHP)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
03
2022
accepted:
20
04
2022
entrez:
2
6
2022
pubmed:
3
6
2022
medline:
7
6
2022
Statut:
epublish
Résumé
T cell-mediated immunity plays a central role in the control and clearance of intracellular
Identifiants
pubmed: 35651616
doi: 10.3389/fimmu.2022.901372
pmc: PMC9149306
doi:
Substances chimiques
Antibodies, Bacterial
0
Bacterial Vaccines
0
Epitopes, T-Lymphocyte
0
Peptides
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
901372Informations de copyright
Copyright © 2022 Sluder, Raju Paul, Moise, Dold, Richard, Silva-Reyes, Baeten, Scholzen, Reeves, Pollard, Garritsen, Bowen, De Groot, Rollier and Poznansky.
Déclaration de conflit d'intérêts
MP, AES, ADG, LM, AG, and AS are named inventors on patent application WO 2019/183627 A1, “Coxiella burnetii epitopes for T cell-targeted Q fever vaccines”. AG is a senior officer and shareholder and AS was an employee of Innatoss Laboratories B.V., which provides diagnostic screening for Q fever. ADG is a senior officer and shareholder, and LM and GR are employees of EpiVax, Inc., a company specializing in immunoinformatic analysis. Innatoss Laboratories B.V and EpiVax, Inc., own patents to technologies utilized by associated authors in the research reported here. AP is Chair of UK Dept. Health and Social Care’s (DHSC) Joint Committee on Vaccination & Immunisation (JCVI), and is a member of the WHO’s SAGE. AP is an NIHR Senior Investigator. The views expressed in this article do not necessarily represent the views of DHSC, JCVI, NIHR or WHO. CR, CD, and AP are named inventors on a patent application in the field of meningococcal vaccines. AP waives all his rights to any patent. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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